Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 2848253..2848917 Replicon chromosome
Accession NZ_CP044411
Organism Acidithiobacillus sp. 'AMD consortium'

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag F6A13_RS14820 Protein ID WP_113527578.1
Coordinates 2848253..2848615 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag F6A13_RS14825 Protein ID WP_113527577.1
Coordinates 2848612..2848917 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6A13_RS14790 2843490..2844404 + 915 WP_126604801.1 magnesium transporter -
F6A13_RS14795 2844374..2845471 - 1098 WP_126604799.1 ADP-ribosylglycohydrolase family protein -
F6A13_RS14800 2845795..2845992 + 198 WP_113527582.1 hypothetical protein -
F6A13_RS14805 2845996..2846868 + 873 WP_126604797.1 pirin family protein -
F6A13_RS14810 2847074..2847751 + 678 WP_126604796.1 DUF541 domain-containing protein -
F6A13_RS14815 2847912..2848205 + 294 Protein_2880 SAM-dependent DNA methyltransferase -
F6A13_RS14820 2848253..2848615 + 363 WP_113527578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F6A13_RS14825 2848612..2848917 + 306 WP_113527577.1 helix-turn-helix domain-containing protein Antitoxin
F6A13_RS14830 2849247..2849453 + 207 Protein_2883 TonB-dependent receptor -
F6A13_RS14835 2849588..2852335 + 2748 WP_192796472.1 quinoprotein amine dehydrogenase, beta chain-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(29-84)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13770.91 Da        Isoelectric Point: 9.9763

>T140925 WP_113527578.1 NZ_CP044411:2848253-2848615 [Acidithiobacillus sp. 'AMD consortium']
MVQSQRPLFWVASAKKDLMDMPEDVRDTFGYALHLAQIGGKHAQAKPLKGFGSADLVEIVEDFKGDTFRAVYTVRFQEKI
YVLHSFQKKATQGIRTPKPDMDKIHERLKWAERHAKGVIE

Download         Length: 363 bp

>T140925 NZ_CP059567:c1649197-1648859 [Neisseria shayeganii]
GTGAAAGCCGTATTTGTCGAACTGCCGCCGTTTTCGCGTTACCGCAGCGATTACTTCACAGACGAAAGTTACCGGGCATT
TCAGAATGAATTGCTGCTCAATCCTGAAAAAGGGGACGTCATTCAAGGCACGGGCGGACTGCGGAAAGTGCGGGTTGCCG
ATATGCAGCGCAATAAAGGCAAACGGGGCGGCTCGCGCGTTATTTACTATTGGTTTTCTGCCCGCTCCCATTTCTTGCTG
TTTACCGTCTACGGCAAGGATATGCAGGACGATTTAAGCCCGGACGAACGTAAAGCACTTGCGGCCATGCTGCGAACCAT
CAAGGAAACACCACTATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10824.62 Da        Isoelectric Point: 5.0349

>AT140925 WP_113527577.1 NZ_CP044411:2848612-2848917 [Acidithiobacillus sp. 'AMD consortium']
MNIEMSSGNVYADIGAPDAEEMLLKAQLASRIADMIQSKGFTQSQAAELLGIPQPKLSLMLRGQFRGISEAKMLECLARL
GRDIQIVIGPEHAGTGNIVVV

Download         Length: 306 bp

>AT140925 NZ_CP059567:c1648862-1648551 [Neisseria shayeganii]
ATGAAACGCAATTTATTTCAAGAGCTGCAAGAGGGCATGGCTGCCGCCGAACAGTATTTGCAAGGCAAAGCCACCCTGAA
AACCGTTACCGTGGAAAAATCCGAACCGGTACACATCGAACCGGCGGAAATACGCGCAATCCGTGAACAGCTCAATCTTT
CGCAAGCGGTGTTTGCTGCCAAGCTGCGCACTTCCGTTCGCACCTACCAAGGCTGGGAACAGGGCAAAACCCGCCCCAAT
CCTCAAGCAGCCTTGCTGCTGCGCATGGTGCAAAAGTCACCCAAAACCTTTAAGGCCATTGCTTCGGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References