Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3483077..3483744 Replicon chromosome
Accession NZ_CP044410
Organism Escherichia coli strain ecMN1F

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag FNW43_RS16925 Protein ID WP_001094400.1
Coordinates 3483415..3483744 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag FNW43_RS16920 Protein ID WP_000072690.1
Coordinates 3483077..3483394 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNW43_RS16890 3478129..3479138 - 1010 Protein_3258 arsenic transporter -
FNW43_RS16895 3479280..3480983 + 1704 WP_000896263.1 hypothetical protein -
FNW43_RS16900 3481555..3481778 + 224 Protein_3260 DUF905 family protein -
FNW43_RS16905 3481881..3482339 + 459 WP_000211841.1 antirestriction protein -
FNW43_RS16910 3482348..3482830 + 483 WP_001407480.1 RadC family protein -
FNW43_RS16915 3482839..3483039 + 201 WP_001395452.1 DUF987 domain-containing protein -
FNW43_RS16920 3483077..3483394 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FNW43_RS16925 3483415..3483744 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
FNW43_RS16930 3484108..3488688 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - luxS 3462124..3536739 74615


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T140905 WP_001094400.1 NZ_CP044410:3483415-3483744 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

>T140905 NZ_CP059557:6004752-6005003 [Saccharopolyspora gloriosae]
ATGAAAACCATGTCGTACTCGGAATCTCGTGCGAAGTACGCCGAGACGCTCAACTCCGTCGTCGACGATCGCGAGGAAGT
GGTGATCACTCGCTCCGGACACGAACCGGTGGTGATGGTCGCGCTCGATGACTACGAGTCGTTGAAGGAGACGGCCTACC
TGCTCAAGAGCCCGGAGAACGCGCGCCGCCTGCTCGCCTCCATCGAGCGCTTGGAACACGGTGGCGGCACGACTCGGGAC
CTCATCGAATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT140905 WP_000072690.1 NZ_CP044410:3483077-3483394 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT140905 NZ_CP059557:6005000-6005260 [Saccharopolyspora gloriosae]
ATGAAGTTGGTCTGGGATGAGAACGCCTGGGACGACTACGTCTGGTGGCAGACCCAAGACCGCAAAGTCCTCAAACGGAT
CAACGCGCTACTGAAGGATGTAGAGCGGAACGGGAACGAAGGAATCGGCAAGCCGGAGCCGCTCAAACACGGCTTCCACG
GGTTCTGGTCACGCCGAATCACCGACGAACATCGCCTCGTTTACCGGCTACAAGAAGATCAAATTCAGATCGCCTCGTGC
CGGTACCACTACGGCAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
PDB 2EA9
PDB 2JN7
AlphaFold DB P52141

References