Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2955833..2956614 Replicon chromosome
Accession NZ_CP044407
Organism Actinomadura sp. WMMB 499 strain WMMB499

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag F7P10_RS12755 Protein ID WP_151009541.1
Coordinates 2956102..2956614 (+) Length 171 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag F7P10_RS12750 Protein ID WP_151009540.1
Coordinates 2955833..2956105 (+) Length 91 a.a.

Genomic Context

F7P10_RS12740F7P10_RS12750F7P10_RS12755F7P10_RS12730F7P10_RS12735F7P10_RS12745F7P10_RS12760F7P10_RS12765F7P10_RS12770F7P10_RS12775F7P10_RS12780
Location: 2953482..2954897 (1416 bp)
Type: Others
Protein ID: WP_151018005.1
Location: 2955833..2956105 (273 bp)
Type: Antitoxin
Protein ID: WP_151009540.1
Location: 2956102..2956614 (513 bp)
Type: Toxin
Protein ID: WP_151009541.1
Location: 2951009..2951896 (888 bp)
Type: Others
Protein ID: WP_151009537.1
Location: 2951899..2953077 (1179 bp)
Type: Others
Protein ID: WP_151009538.1
Location: 2954894..2955661 (768 bp)
Type: Others
Protein ID: WP_151009539.1
Location: 2956656..2957210 (555 bp)
Type: Others
Protein ID: WP_151009542.1
Location: 2957243..2959480 (2238 bp)
Type: Others
Protein ID: WP_151018006.1
Location: 2959581..2959967 (387 bp)
Type: Others
Protein ID: WP_151009543.1
Location: 2959952..2960638 (687 bp)
Type: Others
Protein ID: WP_176611443.1
Location: 2960593..2961588 (996 bp)
Type: Others
Protein ID: WP_151009544.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
F7P10_RS127302951009..2951896-888WP_151009537.1succinate--CoA ligase subunit alpha-
F7P10_RS127352951899..2953077-1179WP_151009538.1ADP-forming succinate--CoA ligase subunit beta-
F7P10_RS127402953482..2954897+1416WP_151018005.1glycoside hydrolase family 15-
F7P10_RS127452954894..2955661-768WP_151009539.1TSUP family transporter-
F7P10_RS127502955833..2956105+273WP_151009540.1DUF1778 domain-containing proteinAntitoxin
F7P10_RS127552956102..2956614+513WP_151009541.1GNAT family N-acetyltransferaseToxin
F7P10_RS127602956656..2957210-555WP_151009542.1GNAT family N-acetyltransferase-
F7P10_RS127652957243..2959480-2238WP_151018006.1DNA helicase PcrA-
F7P10_RS127702959581..2959967-387WP_151009543.1hypothetical protein-
F7P10_RS127752959952..2960638-687WP_176611443.1dihydroxyacetone kinase subunit L-
F7P10_RS127802960593..2961588-996WP_151009544.1dihydroxyacetone kinase subunit DhaK-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(53-142)

Antitoxin

Vibrio phage ICP1, Orf50

(2-84)


Sequences

Toxin        


Download         Length: 171 a.a.        Molecular weight: 18552.27 Da        Isoelectric Point: 10.3263

>T140868 WP_151009541.1 NZ_CP044407:2956102-2956614 [Actinomadura sp. WMMB 499]
MKLSTVRPLTRDHVLDGFDCGSPAQSGWLTRHALQAHASGTSRVYVVEDLVSESVVGYYALAAGSIGRADAPRRLQRGAG
GYDQPVILLTRLGVDLRAQGAGLGRRLLADALRRVEATADLVGVRALLIHCENEKARGFYRRQARFETSPTDPLHLLLLI
KDLRAALNTR

Download         Length: 513 bp

>T140868 NZ_CP059488:1631500-1631826 [Acidithiobacillus ferrivorans]
ATGAGGCGTGGTGACATTTACCTGGTCTCACTTGATCCGACCGAAGGGCGCGAGCAGCGCGGCAGCCGTCCCGTGCTTGT
CGTGTCGCCTGCCGAGTTCAACGAGGCGACCAAGTTGCCAGTGATTTGCCCGATCACGAACGGCGGCGACTTCGCCCGCC
GCATCGGGTTCGCCGTTCCCGTGACCGGCATCAAGACAACCGGCGTCGTGCGCTGCGATCAACCACGTGTGCTTGATCTT
GGTGCCCGCAACGCCCGCAAGGTGGACACCTTGCCAACATCAATCCTGGAAGAAGTGTTAGCGAAACTTGCTCCGATTTT
CGAGTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9593.53 Da        Isoelectric Point: 4.1310

>AT140868 WP_151009540.1 NZ_CP044407:2955833-2956105 [Actinomadura sp. WMMB 499]
MATKDERINVRVDAEQKSLLEAASEVEHTSVSAFVLSAATSAAADVLADRRAFTLDADAWTAFDEALNRPAHAVEGLREL
LNEAPPGEDG

Download         Length: 273 bp

>AT140868 NZ_CP059488:1631246-1631503 [Acidithiobacillus ferrivorans]
ATGTACACAACCAATCTGCGCAAGGTCGGCGGCTCGGTCATGTTGGTCGTCCCGCCGGCGTTCCTCGATCAACTGCACCT
ACAAGCTGGGGCTACGGTAGGCGTCGTTGTTACTGAAGGCCGCCTAGTGATCGATCCCAAGCCCAGGCCGCGTTACACGC
TCGCGGAGCTGCTGGCCGCGTCGGACTATTCACAACCACAACCGCCTGAAGAACGCGAATGGGTCGATGCGCCCGCCGTG
GGTGGTGAGTTGATATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References