Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2955833..2956614 Replicon chromosome
Accession NZ_CP044407
Organism Actinomadura sp. WMMB 499 strain WMMB499

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag F7P10_RS12755 Protein ID WP_151009541.1
Coordinates 2956102..2956614 (+) Length 171 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag F7P10_RS12750 Protein ID WP_151009540.1
Coordinates 2955833..2956105 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7P10_RS12730 2951009..2951896 - 888 WP_151009537.1 succinate--CoA ligase subunit alpha -
F7P10_RS12735 2951899..2953077 - 1179 WP_151009538.1 ADP-forming succinate--CoA ligase subunit beta -
F7P10_RS12740 2953482..2954897 + 1416 WP_151018005.1 glycoside hydrolase family 15 -
F7P10_RS12745 2954894..2955661 - 768 WP_151009539.1 TSUP family transporter -
F7P10_RS12750 2955833..2956105 + 273 WP_151009540.1 DUF1778 domain-containing protein Antitoxin
F7P10_RS12755 2956102..2956614 + 513 WP_151009541.1 GNAT family N-acetyltransferase Toxin
F7P10_RS12760 2956656..2957210 - 555 WP_151009542.1 GNAT family N-acetyltransferase -
F7P10_RS12765 2957243..2959480 - 2238 WP_151018006.1 DNA helicase PcrA -
F7P10_RS12770 2959581..2959967 - 387 WP_151009543.1 hypothetical protein -
F7P10_RS12775 2959952..2960638 - 687 WP_176611443.1 dihydroxyacetone kinase subunit L -
F7P10_RS12780 2960593..2961588 - 996 WP_151009544.1 dihydroxyacetone kinase subunit DhaK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(53-142)

Antitoxin

Vibrio phage ICP1, Orf50

(2-84)


Sequences

Toxin        


Download         Length: 171 a.a.        Molecular weight: 18552.27 Da        Isoelectric Point: 10.3263

>T140868 WP_151009541.1 NZ_CP044407:2956102-2956614 [Actinomadura sp. WMMB 499]
MKLSTVRPLTRDHVLDGFDCGSPAQSGWLTRHALQAHASGTSRVYVVEDLVSESVVGYYALAAGSIGRADAPRRLQRGAG
GYDQPVILLTRLGVDLRAQGAGLGRRLLADALRRVEATADLVGVRALLIHCENEKARGFYRRQARFETSPTDPLHLLLLI
KDLRAALNTR

Download         Length: 513 bp

>T140868 NZ_CP059488:1631500-1631826 [Acidithiobacillus ferrivorans]
ATGAGGCGTGGTGACATTTACCTGGTCTCACTTGATCCGACCGAAGGGCGCGAGCAGCGCGGCAGCCGTCCCGTGCTTGT
CGTGTCGCCTGCCGAGTTCAACGAGGCGACCAAGTTGCCAGTGATTTGCCCGATCACGAACGGCGGCGACTTCGCCCGCC
GCATCGGGTTCGCCGTTCCCGTGACCGGCATCAAGACAACCGGCGTCGTGCGCTGCGATCAACCACGTGTGCTTGATCTT
GGTGCCCGCAACGCCCGCAAGGTGGACACCTTGCCAACATCAATCCTGGAAGAAGTGTTAGCGAAACTTGCTCCGATTTT
CGAGTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9593.53 Da        Isoelectric Point: 4.1310

>AT140868 WP_151009540.1 NZ_CP044407:2955833-2956105 [Actinomadura sp. WMMB 499]
MATKDERINVRVDAEQKSLLEAASEVEHTSVSAFVLSAATSAAADVLADRRAFTLDADAWTAFDEALNRPAHAVEGLREL
LNEAPPGEDG

Download         Length: 273 bp

>AT140868 NZ_CP059488:1631246-1631503 [Acidithiobacillus ferrivorans]
ATGTACACAACCAATCTGCGCAAGGTCGGCGGCTCGGTCATGTTGGTCGTCCCGCCGGCGTTCCTCGATCAACTGCACCT
ACAAGCTGGGGCTACGGTAGGCGTCGTTGTTACTGAAGGCCGCCTAGTGATCGATCCCAAGCCCAGGCCGCGTTACACGC
TCGCGGAGCTGCTGGCCGCGTCGGACTATTCACAACCACAACCGCCTGAAGAACGCGAATGGGTCGATGCGCCCGCCGTG
GGTGGTGAGTTGATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References