Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 17995..18460 Replicon plasmid pNMBU-W10C18_04
Accession NZ_CP044406
Organism Escherichia coli strain NMBU-W10C18

Toxin (Protein)


Gene name TsxA Uniprot ID M7C8T2
Locus tag F7O57_RS26045 Protein ID WP_001230706.1
Coordinates 18212..18460 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag F7O57_RS26040 Protein ID WP_000801440.1
Coordinates 17995..18222 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7O57_RS26000 13221..13454 - 234 WP_000120384.1 EexN family lipoprotein -
F7O57_RS26005 13459..13725 - 267 WP_000134734.1 hypothetical protein -
F7O57_RS26010 13802..15031 - 1230 WP_001329504.1 relaxase/mobilization nuclease domain-containing protein -
F7O57_RS26015 15035..15538 - 504 WP_000781817.1 hypothetical protein -
F7O57_RS26020 15901..16248 - 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin -
F7O57_RS26025 16245..16493 - 249 WP_000520550.1 type II toxin-antitoxin system HicA family toxin -
F7O57_RS26030 16798..17148 - 351 WP_000854257.1 hypothetical protein -
F7O57_RS26035 17242..17541 - 300 WP_000650312.1 hypothetical protein -
F7O57_RS26040 17995..18222 - 228 WP_000801440.1 hypothetical protein Antitoxin
F7O57_RS26045 18212..18460 - 249 WP_001230706.1 hypothetical protein Toxin
F7O57_RS26050 18457..18999 - 543 WP_001083907.1 hypothetical protein -
F7O57_RS26055 19104..19619 - 516 WP_001025395.1 J domain-containing protein -
F7O57_RS26060 21034..21900 + 867 WP_001353743.1 replication initiation protein -
F7O57_RS26065 21913..22317 + 405 WP_001329491.1 hypothetical protein -
F7O57_RS26070 22453..22980 + 528 WP_000577045.1 DUF2726 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..32448 32448


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9594.94 Da        Isoelectric Point: 7.9925

>T140867 WP_001230706.1 NZ_CP044406:c18460-18212 [Escherichia coli]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLREDDETPVKNLIKEFMLN
ET

Download         Length: 249 bp

>T140867 NZ_CP059488:c1522230-1521802 [Acidithiobacillus ferrivorans]
ATGACCTTCTTGCTCGATGTAAACGTGCTGATTGCGCTCATCGACCCCATGCATGTTCAGCATGATATGGCCCATGAATG
GTTTGCAGCCCATGGGCAACCCGCATGGGCTACCTGTCCCTTAACAGAGAATGGTGTACTGCGCATCGTGGGCCATCCGC
GTTATCCAAATTCACCAGGCACGCCAGCGGCCGTGGCACCGCTGATCCAGGGATTGCGCGCGTCGCCTGGCCATGTTTTT
TGGCCAGACGACATCAGCCTGCTGGATGTCGACCATATCGACGCATCGCGCCTGTTCACTTCTGGTCAGATTACCGATAG
CTACCTCTTGGCGCTGGCCTGCGCCCATGAGGGCCAACTGGTAACCTTCGATCATCGCTTAGTGATCAATGCCGTGCGCA
ACGGTTTGCAATGCATCAACAAAATTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8659.98 Da        Isoelectric Point: 8.5105

>AT140867 WP_000801440.1 NZ_CP044406:c18222-17995 [Escherichia coli]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK

Download         Length: 228 bp

>AT140867 NZ_CP059488:c1522463-1522230 [Acidithiobacillus ferrivorans]
ATGCGCACCACACTGGCGATTGATGATGACGTACTAGCGGCGGCGAAAGGGTTAGCGGATCGACAGCATAAGCCTGTAGG
TGCCGTTGTTTCAGCACTTTTGCGGCAGGCTCTGCAACCGCAAAACACCTCTGGTGGCCATTCACGTAATGGCATTCCCT
TGCTGCCGGTGCGTCCGGATGCACTCCCGGCGACTCTGGAAATAGTGAATCAGTTGCGCGACGAATTGCCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7C8T2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References