Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4251000..4251832 Replicon chromosome
Accession NZ_CP044403
Organism Escherichia coli strain NMBU-W10C18

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3P5UBZ5
Locus tag F7O57_RS20905 Protein ID WP_001094454.1
Coordinates 4251458..4251832 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3G8RJV8
Locus tag F7O57_RS20900 Protein ID WP_001320394.1
Coordinates 4251000..4251368 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7O57_RS20865 4247287..4247742 + 456 WP_000581493.1 hypothetical protein -
F7O57_RS20870 4247821..4248054 + 234 WP_001119719.1 DUF905 family protein -
F7O57_RS20875 4248154..4248972 + 819 WP_001234642.1 DUF945 domain-containing protein -
F7O57_RS20880 4249027..4249512 + 486 WP_029701480.1 antirestriction protein -
F7O57_RS20885 4249528..4250004 + 477 WP_001347688.1 RadC family protein -
F7O57_RS20890 4250067..4250288 + 222 WP_000692300.1 DUF987 domain-containing protein -
F7O57_RS20895 4250307..4250950 + 644 Protein_4007 antitoxin of toxin-antitoxin stability system -
F7O57_RS20900 4251000..4251368 + 369 WP_001320394.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
F7O57_RS20905 4251458..4251832 + 375 WP_001094454.1 TA system toxin CbtA family protein Toxin
F7O57_RS20910 4251829..4252317 + 489 WP_000777545.1 hypothetical protein -
F7O57_RS20915 4252329..4252526 + 198 WP_000839276.1 DUF957 domain-containing protein -
F7O57_RS20920 4252623..4253192 + 570 WP_001290250.1 DUF4942 domain-containing protein -
F7O57_RS20925 4253535..4253705 + 171 Protein_4013 IS110 family transposase -
F7O57_RS20930 4254516..4255499 + 984 WP_001298261.1 KpsF/GutQ family sugar-phosphate isomerase -
F7O57_RS20935 4255571..4256719 + 1149 WP_000905922.1 capsule polysaccharide export inner-membrane protein KpsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14059.10 Da        Isoelectric Point: 9.2447

>T140857 WP_001094454.1 NZ_CP044403:4251458-4251832 [Escherichia coli]
MNTLPDTHVRKASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T140857 NZ_CP059484:52335-52817 [Enterobacter kobei]
GTGGGACGTGTAACAGCACCAGAACCGCTATCCAGTTCACACCAGCTCGCAGAATTCGTCAGTGGCGAGAGTGTACTCGA
TGAATGGCTTAAACAGCGAGGGCTTAAGAATCAGGCTCTCGGGGCCGCCCGAACGTTCGTTGTCTGCAAATCCGGCACGA
AGCAAGTCGCTGGCTTTTACTCTCTGGCCACTGGCAGCGTTAACCATACGGAATCCACAGGTAGTCTTCGGCGCAACATG
CCGGACCCTATACCGGTCATCATACTTGCTCGTCTTGCAGTCGATGTTGCATTCCGTGGAAAAGGGATCGGCGCCGATCT
GCTTCACGATGCGGTGCTGCGTTGTTATCGGGTTGCTGAGAATATCGGTGTACGTGCGATCATGGTTCACGCGCTTACTG
AAGAAGCCAAAGGCTTTTATCTGTACCACGGCTTTAAGGCTTCAAATACACAGGAACGCACATTATTCCTGAAACTACCT
TGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13623.22 Da        Isoelectric Point: 6.4783

>AT140857 WP_001320394.1 NZ_CP044403:4251000-4251368 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Download         Length: 369 bp

>AT140857 NZ_CP059484:52081-52347 [Enterobacter kobei]
ATGAAATCAGATGTTCAGCTCAATCTTAGAGCCAAAGAATCTCAGCGGGCACTCATTGATGCTGCGGCAGAGATCCTTCA
TAAATCCCGTACAGACTTTATCCTGGAAATGGCATGTCAGGCGGCGGAGAATGTGATTCTCGACCGCCGCGTATTCAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGCTATGCTCGATGAACCGGTTGCGGATGACCCAGCCATCGATAAGCTGTTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3P5UBZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8RJV8

References