Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4158583..4159243 Replicon chromosome
Accession NZ_CP044403
Organism Escherichia coli strain NMBU-W10C18

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag F7O57_RS20410 Protein ID WP_029701967.1
Coordinates 4158583..4158996 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag F7O57_RS20415 Protein ID WP_000354046.1
Coordinates 4158977..4159243 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7O57_RS20390 4154547..4156280 - 1734 WP_029701971.1 single-stranded-DNA-specific exonuclease RecJ -
F7O57_RS20395 4156286..4156996 - 711 WP_029701969.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F7O57_RS20400 4157020..4157916 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
F7O57_RS20405 4158028..4158549 + 522 WP_001055874.1 flavodoxin FldB -
F7O57_RS20410 4158583..4158996 - 414 WP_029701967.1 protein YgfX Toxin
F7O57_RS20415 4158977..4159243 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
F7O57_RS20420 4159486..4160466 + 981 WP_000886083.1 tRNA-modifying protein YgfZ -
F7O57_RS20425 4160543..4161202 - 660 WP_000250274.1 hemolysin III family protein -
F7O57_RS20430 4161366..4161677 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
F7O57_RS20435 4161722..4163155 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
F7O57_RS20440 4163212..4163955 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16305.25 Da        Isoelectric Point: 11.7064

>T140856 WP_029701967.1 NZ_CP044403:c4158996-4158583 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLLHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQRSR

Download         Length: 414 bp

>T140856 NZ_CP059483:c43041-42625 [Enterobacter kobei]
GTGAACAAAATTTACATGCTCGACACCTGTATCTGCTCATTCATCATGCGCGAGCAGCCGGAAGCGGTGCTGAAGCGGCT
GGAGCAGGCGGTACTGCGCAATCACCGGATCGTGGTTTCGGCCATCACCTACGCCGAGATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGACATATTCAGCTGGTTGACGCGTTCTGCGCCCGCCTCGATGCCGTCCTGCCCTGGGATCGCGCC
GCGGTCGACGCCACCACGGAGATTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGCCCGAACGACACGGCGATCGC
CGGGCACGCCATTGCCGCCGGCGCCGTACTGGTGACGAATAATACAAGGGAGTTTGCGCGGGTGCCGGGCCTGATACTGG
AAGACTGGGTTAACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT140856 WP_000354046.1 NZ_CP044403:c4159243-4158977 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT140856 NZ_CP059483:c43268-43038 [Enterobacter kobei]
ATGAGAACCGTATCCATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
AAAAAGCAGACGCGGACTTTATGGCGGAGCGCGAGGACGTTGTCACCGACGAAGGACGGGTTGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References