Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 445796..446631 Replicon chromosome
Accession NZ_CP044403
Organism Escherichia coli strain NMBU-W10C18

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J1YPH7
Locus tag F7O57_RS02355 Protein ID WP_029701676.1
Coordinates 445796..446173 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag F7O57_RS02360 Protein ID WP_001295723.1
Coordinates 446263..446631 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7O57_RS02335 442163..443701 - 1539 WP_001187196.1 lysine decarboxylation/transport transcriptional activator CadC -
F7O57_RS02340 444450..445292 - 843 WP_022645115.1 DUF4942 domain-containing protein -
F7O57_RS02345 445377..445571 - 195 WP_024181941.1 DUF957 domain-containing protein -
F7O57_RS02350 445650..445799 - 150 Protein_376 hypothetical protein -
F7O57_RS02355 445796..446173 - 378 WP_029701676.1 TA system toxin CbtA family protein Toxin
F7O57_RS02360 446263..446631 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
F7O57_RS02365 446794..447015 - 222 WP_000692345.1 DUF987 domain-containing protein -
F7O57_RS02370 447080..447556 - 477 WP_021553055.1 RadC family protein -
F7O57_RS02375 447572..448051 - 480 WP_001564060.1 antirestriction protein -
F7O57_RS02380 448317..449135 - 819 WP_001175165.1 DUF945 domain-containing protein -
F7O57_RS02385 449225..449458 - 234 WP_001278293.1 DUF905 family protein -
F7O57_RS02390 449464..450141 - 678 WP_001097302.1 hypothetical protein -
F7O57_RS02395 450289..450969 - 681 WP_029702103.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 434675..480425 45750


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14066.04 Da        Isoelectric Point: 7.8045

>T140826 WP_029701676.1 NZ_CP044403:c446173-445796 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T140826 NZ_CP059468:c1946637-1946419 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT140826 WP_001295723.1 NZ_CP044403:c446631-446263 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT140826 NZ_CP059468:c1947038-1946664 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1YPH7

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References