Detailed information of TA system TA140818

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 3006846..3008388
• Replicon: chromosome
• Accession: NZ_CP044399
• Organism: Moritella marina ATCC 15381 strain MP-1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A5J6WMV3
• Locus tag: FR932_RS13455
• Protein ID: WP_019439627.1
• Coordinates: 3006846..3008153 (-)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: FR932_RS13460
• Protein ID: WP_019439628.1
• Coordinates: 3008140..3008388 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR932_RS13435	3003109..3003516	+	408	WP_019439623.1	hypothetical protein	-
FR932_RS13440	3003781..3004989	+	1209	WP_019439624.1	DUF3103 family protein	-
FR932_RS13445	3005156..3006079	-	924	WP_019439625.1	helix-turn-helix domain-containing protein	-
FR932_RS13450	3006179..3006742	+	564	WP_019439626.1	cysteine hydrolase	-
FR932_RS13455	3006846..3008153	-	1308	WP_019439627.1	HipA domain-containing protein	Toxin
FR932_RS13460	3008140..3008388	-	249	WP_019439628.1	helix-turn-helix domain-containing protein	Antitoxin
FR932_RS13475	3010409..3011515	+	1107	WP_019441473.1	EAL domain-containing protein	-
FR932_RS13480	3011892..3013238	+	1347	WP_019441472.1	ISNCY family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (10-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (11-65)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 49785.24 Da
• Isoelectric Point: 5.0477

>T140818 WP_019439627.1 NZ_CP044399:c3008153-3006846 [Moritella marina ATCC 15381]
MSGSNFNTLEMHFRGMIIGEICFDIDTQYFSIEYTKEWQEKGFPISPKLPLSGRVPSSQISIYLTNLLPENKGLDYLIEA
LGISKNNTFALIKGIGFDTSGAILYLPVDAKPQVTSFTSICEDDLIKRIEDPEMWPMEVWDGKPRLSVAGVQSKLNLFHI
DNKYGFGEGELCSTHIVKFEKNTQQHLVLNEFITMKLAELIGMQVAKVEAMPIGKYKALSVTRFDRMYNAERKIVMRRHM
IDACQALGFSVARKYERNLGSSRDVKEIREGVSLEKLFSIAQHCVNPAQAKYDMLRWTIFNLLICNADSHGKNYSFYVTA
DGLEPTPWYDLVNVQMYPEFDQELAMAIGDEFEPDEVHAYQLMLFAEECGIKQSVLEITLKQLAKAIINNVDKAVNLAWE
LSDAEFEYTEKYKHSIQARCEYYLAQTEEMKHILL

Nucleotide

• Length: 1308 bp

>T140818 NZ_CP059467:3735844-3736071 [Aromatoleum bremense]
ATGGAGGAGCACGGTGCCGACCTGCGCCTACCGCACTCTCGCGCCATGGGCGATGGCCTCTTCGAGCTGCGCTGCAAGGG
TGAGGAAGGAATTGGCCGAGTGTTCTACTGCACGTTGGTCGGACGCCAGATCGTCATCCTGCACAGCTTCATCAAGAAGA
CGCAGGAAACTCCAGACCGGGAGCTGAAGACTGCCCGCAAGCGACTGAAGGAGGTCAAACATGGATAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8842.24 Da
• Isoelectric Point: 9.0790

>AT140818 WP_019439628.1 NZ_CP044399:c3008388-3008140 [Moritella marina ATCC 15381]
MVTQLDPITLGKLIKDHRKAASMTQEIAASFCGVTKKTLIRVEKGEDVYFSTIVKILNGLGISLAADTPSSKNTVGGSNE
WF

Nucleotide

• Length: 249 bp

>AT140818 NZ_CP059467:3736064-3736375 [Aromatoleum bremense]
ATGGATAGAGAGCATTTCAAGCCGGTTCGCCTGGACACCAAGGCGGAACTTGCCCGTGCCATGCAACGGCCGGGATTCAA
GGCTGCGTGGGACGGACTGGAGGAAGAGTACGCGGCACTCAACGAGCTGCTCCAGGCGCGCAAGCAAGCCGGCCTGACGC
AGGAAGAAGTCGCTGCCCGCATGGGCACGACCAAGAGCGCCGTGTCGCGTTTGGAAGCATCCATTCGTAGCGAAAGCCAT
TCGCCCTCGTTCGCGACGCTGCGCAAGTACGCGCACGCTTGCGGCAAGCGACTGGTCATCAAGATGGTCTAA

Structures

Toxin

• AlphaFold DB: A0A5J6WMV3