Detailed information of TA system TA140815

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 1945211..1945719
• Replicon: chromosome
• Accession: NZ_CP044399
• Organism: Moritella marina ATCC 15381 strain MP-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5J6WLL2
• Locus tag: FR932_RS08740
• Protein ID: WP_019441148.1
• Coordinates: 1945459..1945719 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A5J6WIF7
• Locus tag: FR932_RS08735
• Protein ID: WP_019441147.1
• Coordinates: 1945211..1945462 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR932_RS21545	1940528..1940632	-	105	Protein_1672	lactoylglutathione lyase	-
FR932_RS08695	1940732..1941571	-	840	WP_019441141.1	DMT family transporter	-
FR932_RS08705	1941816..1942166	-	351	WP_019441142.1	ribonuclease E inhibitor RraB	-
FR932_RS08710	1942233..1942607	-	375	WP_019441143.1	GFA family protein	-
FR932_RS08715	1942658..1943083	-	426	WP_019441144.1	TerB family tellurite resistance protein	-
FR932_RS08720	1943512..1944306	+	795	WP_019441145.1	aminoglycoside 6-adenylyltransferase	-
FR932_RS08725	1944371..1944684	-	314	Protein_1678	type II toxin-antitoxin system MqsA family antitoxin	-
FR932_RS08735	1945211..1945462	+	252	WP_019441147.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FR932_RS08740	1945459..1945719	+	261	WP_019441148.1	Txe/YoeB family addiction module toxin	Toxin
FR932_RS08745	1945808..1946257	-	450	WP_019441149.1	hypothetical protein	-
FR932_RS08750	1946402..1946608	-	207	WP_019441150.1	hypothetical protein	-
FR932_RS08760	1947121..1948068	-	948	WP_019441152.1	alpha/beta hydrolase	-
FR932_RS08765	1948245..1948775	-	531	WP_019441153.1	GNAT family N-acetyltransferase	-
FR932_RS08770	1948893..1949141	-	249	WP_081588316.1	DUF1272 domain-containing protein	-
FR932_RS21450	1949411..1949557	-	147	WP_017019179.1	hypothetical protein	-
FR932_RS08775	1949854..1950418	+	565	Protein_1687	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1949854..1950192	338

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10411.07 Da
• Isoelectric Point: 10.3515

>T140815 WP_019441148.1 NZ_CP044399:1945459-1945719 [Moritella marina ATCC 15381]
MKLTFSTKAWEQYLYWQTTDKRILKRINLLIKDIQRTPTEGIGKPEPLKHGLAGYWSRRINDEHRIVYKHRDDTILIAQL
RYHYGI

Nucleotide

• Length: 261 bp

>T140815 NZ_CP059467:3585591-3585938 [Aromatoleum bremense]
GTGAGCTTTGAACGCTTTGCTGTCGTGCGCGTGCCCTTTCCGTTCACCGACCGCAACGCCACCAAGAATCGCCCCGCGCT
GGTGCTCTCGAACGCGGCGGCTTTCAACACGCCCGCGGGCCATTCGGTCATGGCCATGATCACGTCCGAGGCAAACGCCC
CCTGGCCGCTTGATTGCAGGATCGCCGACCTGGCTGCAGCGGGCCTGCCGGCGCCCTCCAAGGTGCGATTCAAGTTGTTT
ACGCTCGACCATCGTCTGGTCAGAGGTCAGATCGGAAAGCTGTCGCCAAGCGACAGCGAAGTCGTTCGCGCCGGGCTGAC
CGCGCTGCTCGACGAGGCGCAGCCTTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9123.35 Da
• Isoelectric Point: 4.5318

>AT140815 WP_019441147.1 NZ_CP044399:1945211-1945462 [Moritella marina ATCC 15381]
MDAISYTAARANLANTMANVCNDHAPIIITRKSEAPVVMMSLEDYNAMKETTYLLRSPANARHLLDSIAELEAGNGTERE
LIE

Nucleotide

• Length: 252 bp

>AT140815 NZ_CP059467:3585371-3585601 [Aromatoleum bremense]
ATGCTTGCTGTTGCCAAGATCACTGCCAAGGGTCAGACCACCATCCCCCAGGACGTGCGCGCCGCGCTGCATGTGAAGCC
GGGCGACTTGATCGCCTGGGACGTCGGCGCTGACGGAACGGCGACGGTGCGCCGAGTGCAGCCGCTGGATGTCGAATACC
TACGCGCCGTCGAGGGCACGCTGTCCGAATGGGCTGGCGAGGCCGACGAGGAAGCCTACCGTGAGCTTTGA

Structures

Toxin

• AlphaFold DB: A0A5J6WLL2

Antitoxin

• AlphaFold DB: A0A5J6WIF7