Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 1619691..1620487 Replicon chromosome
Accession NZ_CP044399
Organism Moritella marina ATCC 15381 strain MP-1

Toxin (Protein)


Gene name - Uniprot ID A0A5J6WHW4
Locus tag FR932_RS07340 Protein ID WP_019628766.1
Coordinates 1619691..1620221 (-) Length 177 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5J6WJI6
Locus tag FR932_RS07345 Protein ID WP_019440103.1
Coordinates 1620218..1620487 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR932_RS07315 1614978..1615163 + 186 WP_019440108.1 hypothetical protein -
FR932_RS07320 1615274..1617052 - 1779 WP_019440107.1 YdiU family protein -
FR932_RS21530 1617288..1617371 - 84 Protein_1395 monofunctional biosynthetic peptidoglycan transglycosylase -
FR932_RS21535 1617366..1617461 - 96 Protein_1396 AraC family transcriptional regulator -
FR932_RS07325 1617503..1618252 - 750 WP_026032050.1 SDR family oxidoreductase -
FR932_RS07330 1618363..1618689 - 327 WP_019440105.1 N(4)-acetylcytidine aminohydrolase -
FR932_RS07335 1618843..1619511 - 669 WP_019440104.1 hypothetical protein -
FR932_RS07340 1619691..1620221 - 531 WP_019628766.1 GNAT family N-acetyltransferase Toxin
FR932_RS07345 1620218..1620487 - 270 WP_019440103.1 DUF1778 domain-containing protein Antitoxin
FR932_RS07350 1620880..1621743 - 864 WP_019628765.1 class A beta-lactamase -
FR932_RS07355 1621982..1623598 - 1617 WP_019440101.1 PfaD family polyunsaturated fatty acid/polyketide biosynthesis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(96-155)

Antitoxin

Vibrio phage ICP1, Orf50

(5-80)


Sequences

Toxin        


Download         Length: 177 a.a.        Molecular weight: 19913.18 Da        Isoelectric Point: 9.5090

>T140814 WP_019628766.1 NZ_CP044399:c1620221-1619691 [Moritella marina ATCC 15381]
VSYSKRFKELDKSKHDRASFDCGEKELNDFIQTQAAKHMQAGISRTLVLPASAPLPNKKYPICSFYSIAPSSISRDTLPQ
AMAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIKALEYLWEINSHMRAYAIVVDCLTEQAESFYAKYGFDVLCEING
RVRMFISMKTVNQLFT

Download         Length: 531 bp

>T140814 NZ_CP059467:c3237090-3236659 [Aromatoleum bremense]
ATGCTCGATACCAACCTCTGCATCTACCTCATCAATCATCGCCCGGCCCACGTGCGCGCCCGCTTCGATGCGCACCCGAT
CGGCGACATCGGCGTATCGGTCATCACCGCCGCGGAGCTCGCGTATGGCGTAACGAAAAGCGCTTCGGCCCGCAACCGCG
CGGCGCTGGAAACCTTCCTGCTGCCGCTGGAAGTGGCCCCCTTTGACGACAAGGCAATCTGGCGCTATGCCGAACTGCGC
ACGCAACTGATGCGACGCGGCACCCCGATCGGCGCGCTCGACACCCAGATCGCCGCGCATGCGCTTGCGCTTGACTGCAC
ACTGGTCACCAACAACATGCGCGAATTCGAACGGGTTGATGGCCTGCGCCTGGAAAACTGGGCCGACCAGCGCCTGATGG
AATCCCCTGCCTCTTACTTCACCGCTCCATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9806.17 Da        Isoelectric Point: 4.4290

>AT140814 WP_019440103.1 NZ_CP044399:c1620487-1620218 [Moritella marina ATCC 15381]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDSTKVVSEHESITVEANVFDQFMAACDEAKAPNKALLEAA
VFTQNGEFK

Download         Length: 270 bp

>AT140814 NZ_CP059467:c3237326-3237096 [Aromatoleum bremense]
ATGGATACCGCCAAGCTTTTCACCAACGGCCGCAGCCAGGCGGTACGCCTGCCCAAGGAGTTCCGCTTCGAGGGTGACGA
AGTGTTCATCAAGCGCGTCGGCGACGCGGTCGTGCTGCTGCCGCGCCACGGCTGGGGTACGCTGTTCGGGGCGCTGGAGG
CCTTCGAGCCAGGGTTCACGATCGAGCGCGACGCGCCGGAACAAGCGGAACGCGAGGCGCTGTTGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5J6WHW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5J6WJI6

References