Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 440715..441352 | Replicon | chromosome |
| Accession | NZ_CP044360 | ||
| Organism | Bacillus amyloliquefaciens strain V167 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G4NU33 |
| Locus tag | BACIH_RS02255 | Protein ID | WP_003156187.1 |
| Coordinates | 441002..441352 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | I2HMS5 |
| Locus tag | BACIH_RS02250 | Protein ID | WP_003156188.1 |
| Coordinates | 440715..440996 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BACIH_RS02230 | 437080..437679 | - | 600 | WP_003156193.1 | rhomboid family intramembrane serine protease | - |
| BACIH_RS02235 | 437772..438137 | + | 366 | WP_012116869.1 | holo-ACP synthase | - |
| BACIH_RS02240 | 438302..439309 | + | 1008 | WP_007410230.1 | outer membrane lipoprotein carrier protein LolA | - |
| BACIH_RS02245 | 439426..440595 | + | 1170 | WP_012116870.1 | alanine racemase | - |
| BACIH_RS02250 | 440715..440996 | + | 282 | WP_003156188.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
| BACIH_RS02255 | 441002..441352 | + | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| BACIH_RS02260 | 441471..442292 | + | 822 | WP_003156182.1 | STAS domain-containing protein | - |
| BACIH_RS02265 | 442297..442662 | + | 366 | WP_003156180.1 | RsbT antagonist protein RsbS | - |
| BACIH_RS02270 | 442665..443066 | + | 402 | WP_003156178.1 | anti-sigma regulatory factor | - |
| BACIH_RS02275 | 443078..444085 | + | 1008 | WP_007410233.1 | PP2C family protein-serine/threonine phosphatase | - |
| BACIH_RS02280 | 444149..444478 | + | 330 | WP_003156176.1 | anti-sigma factor antagonist RsbV | - |
| BACIH_RS02285 | 444475..444957 | + | 483 | WP_007609591.1 | anti-sigma B factor RsbW | - |
| BACIH_RS02290 | 444923..445711 | + | 789 | WP_003156171.1 | RNA polymerase sigma factor SigB | - |
| BACIH_RS02295 | 445711..446313 | + | 603 | WP_012116871.1 | SpoIIE family protein phosphatase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T140810 WP_003156187.1 NZ_CP044360:441002-441352 [Bacillus amyloliquefaciens]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T140810 NZ_CP059467:c895569-895063 [Aromatoleum bremense]
ATGAGCACGGGCAAGCACGCGCCCCTGGTCATTCACGGCTGGACGATCTTTGCCCACCCGCTATTCCTCGCACAGATTGA
AGCGCTGGCGCATCAGGTCGAGGCCTTGAAACAGAAAGATCCGACCGGGTACAACAAGAAGAACGCCAGCAAGCGCCTTG
CGGCGATCACCAAGCTCGCTTTCGACGTCGTCCCGCAAGACCCGGCCCGTCCTGAATACCGCCAAGGCGGCACCCTTGGC
GACGATCACAAGCACTGGTTCCGGGCGAAATTCTTCCAGCAGTACCGGCTCTTCTTCCGGTACCACGCGCCCAGCAAGGT
GATCGTGTTCGCGTGGGTCAACGACGAGGATACCAAGCGCGCCTATGAGAGCAGCGACGACGCCTACCGGGTGTTTCGCA
AGATGCTGGAAAGCGGCCATCCGCCGGATGACTGGAACCAGTTGCTGGCCGAGGCCCGGGCCGAGGGGGAGCGCTTGCAG
CGGTTCGCCGCTGGCGTCACGCCGTAA
ATGAGCACGGGCAAGCACGCGCCCCTGGTCATTCACGGCTGGACGATCTTTGCCCACCCGCTATTCCTCGCACAGATTGA
AGCGCTGGCGCATCAGGTCGAGGCCTTGAAACAGAAAGATCCGACCGGGTACAACAAGAAGAACGCCAGCAAGCGCCTTG
CGGCGATCACCAAGCTCGCTTTCGACGTCGTCCCGCAAGACCCGGCCCGTCCTGAATACCGCCAAGGCGGCACCCTTGGC
GACGATCACAAGCACTGGTTCCGGGCGAAATTCTTCCAGCAGTACCGGCTCTTCTTCCGGTACCACGCGCCCAGCAAGGT
GATCGTGTTCGCGTGGGTCAACGACGAGGATACCAAGCGCGCCTATGAGAGCAGCGACGACGCCTACCGGGTGTTTCGCA
AGATGCTGGAAAGCGGCCATCCGCCGGATGACTGGAACCAGTTGCTGGCCGAGGCCCGGGCCGAGGGGGAGCGCTTGCAG
CGGTTCGCCGCTGGCGTCACGCCGTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10562.92 Da Isoelectric Point: 6.4706
>AT140810 WP_003156188.1 NZ_CP044360:440715-440996 [Bacillus amyloliquefaciens]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT140810 NZ_CP059467:c895895-895566 [Aromatoleum bremense]
ATGCCTGCCACCCTCGACGTCGAATCCACGTTGACCGACCGTTATCAAACCACGGTGCCGGAAACCGTGCGTCGCGCCCT
GCGGCTGGGCAAGCGCGACAAGATTCACTACAGCATCCGCCCCAGTGGCGAGGTGGTGCTGACCCGCGCTGCAAGCCACG
AAGGTGACGACCCGGTGCTCGGGCAGTTCCTGGGCTTTCTGGCCCGCGACATTGCCAGCCATCCCGAGCGCCTGCAGGCG
GTGGATGCGGGCCTTGTCCAACGGCTCCAGTCGCTGGTCGGTGGCATCGAGGTCGATCTTGATGCTGCCCTGTCAGCAGA
CGATGAATGA
ATGCCTGCCACCCTCGACGTCGAATCCACGTTGACCGACCGTTATCAAACCACGGTGCCGGAAACCGTGCGTCGCGCCCT
GCGGCTGGGCAAGCGCGACAAGATTCACTACAGCATCCGCCCCAGTGGCGAGGTGGTGCTGACCCGCGCTGCAAGCCACG
AAGGTGACGACCCGGTGCTCGGGCAGTTCCTGGGCTTTCTGGCCCGCGACATTGCCAGCCATCCCGAGCGCCTGCAGGCG
GTGGATGCGGGCCTTGTCCAACGGCTCCAGTCGCTGGTCGGTGGCATCGAGGTCGATCTTGATGCTGCCCTGTCAGCAGA
CGATGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|