Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 3250642..3251167 Replicon chromosome
Accession NZ_CP044356
Organism Acinetobacter baumannii strain CAM180-1

Toxin (Protein)


Gene name relE Uniprot ID R9B9L0
Locus tag ABCAM1_RS15900 Protein ID WP_005134734.1
Coordinates 3250642..3250929 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3F3MMG8
Locus tag ABCAM1_RS15905 Protein ID WP_005134732.1
Coordinates 3250919..3251167 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABCAM1_RS15890 3245986..3248736 - 2751 WP_000990825.1 bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase -
ABCAM1_RS15895 3248805..3250073 - 1269 WP_000194108.1 HAMP domain-containing histidine kinase -
ABCAM1_RS15900 3250642..3250929 - 288 WP_005134734.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ABCAM1_RS15905 3250919..3251167 - 249 WP_005134732.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ABCAM1_RS15910 3251170..3251601 - 432 WP_111034461.1 hypothetical protein -
ABCAM1_RS15915 3251671..3252284 - 614 Protein_3069 recombinase family protein -
ABCAM1_RS15920 3253801..3254466 + 666 WP_151000828.1 hypothetical protein -
ABCAM1_RS15925 3254540..3254803 + 264 WP_071209756.1 hypothetical protein -
ABCAM1_RS15930 3254839..3256137 - 1299 WP_071209757.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11073.89 Da        Isoelectric Point: 10.1961

>T140804 WP_005134734.1 NZ_CP044356:c3250929-3250642 [Acinetobacter baumannii]
MTYKLDFLEEALAEWNKLNPSIKQPLKKKLIKVLENPRIPKNKLSGHPNRYKIKLRSIGYRLVYEVIDDEVVVIVIAVGR
RENNAVYDDANSRHS

Download         Length: 288 bp

>T140804 NZ_CP059447:2646357-2646779 [Cellulosimicrobium cellulans]
GTGAGCCCGCTCTACCTGCTGGACACGAACGTCCTGATCGCGTTGTTGCGTGGGAACGGCGTGGCCGCGCGACCGAGGCT
TCGGGAGGCGGAGGGGCGCGTCGCGGTCTCGACGGTGAGCGAGATGGAGCTCGAATACGGCATCGAGCGGTCAGACGACC
CGCATCGCAACCGTCAGGCTGTCGACGACCTGTTGTCGCTCGTGGACGTACTCCCCTTCGATGGGCTCGCGGCGATGCAC
GCCGGCCGCGTCCGCGCGCGCCTCGCGGCCCGCGGCACGCCCATCGGACCCTATGACGCCCTCCTCGCCGGGCACGCCCG
TTCGCTCGGGCTCGTCATGGTGACGAACAACGTCCGCGAGTTCTCCCGCGTCCCCGGCCTCGAGGTCGAGGACTGGCTGG
CGGAAGCACCGAGCGATCGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9262.72 Da        Isoelectric Point: 5.0491

>AT140804 WP_005134732.1 NZ_CP044356:c3251167-3250919 [Acinetobacter baumannii]
MTQLIHARMTASITELKKSPMDTVLAGKGEPVAILNRNTPAFYCVPADLYETMMEQLEDLELNKIADTRANQKRVRVNID
DL

Download         Length: 249 bp

>AT140804 NZ_CP059447:2646127-2646360 [Cellulosimicrobium cellulans]
ATGGTCCGCACGACGGTGTTCCGTAGCAACAGGACGCAGGCAGTCCGCCTGCCCAAGGCGGTCGCGCTGCCCGACGACGT
CCGCGAGGTCGAGGTCCGGACCGTGGGCAGGTCCCGCGTGATCACGCCGGCTGGCACCGGGTGGGACGAGTGGTTCGACC
ACGGGCTCCGCGTCGCCGACGACTTCCTGCCCGACCGCGACCAGGGGAACGCCGAGGAGCGCGGCGCCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R9B9L0

Antitoxin

Source ID Structure
AlphaFold DB A0A3F3MMG8

References