Detailed information of TA system TA140803

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1254227..1254906
• Replicon: chromosome
• Accession: NZ_CP044356
• Organism: Acinetobacter baumannii strain CAM180-1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: ABCAM1_RS06180
• Protein ID: WP_000838146.1
• Coordinates: 1254227..1254409 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: ABCAM1_RS06185
• Protein ID: WP_000966688.1
• Coordinates: 1254502..1254906 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABCAM1_RS06140	1249240..1249629	+	390	WP_000008494.1	hypothetical protein	-
ABCAM1_RS06145	1249631..1249999	+	369	WP_025468626.1	hypothetical protein	-
ABCAM1_RS06150	1250055..1250474	+	420	WP_016654269.1	hypothetical protein	-
ABCAM1_RS06155	1250474..1250926	+	453	WP_002053117.1	hypothetical protein	-
ABCAM1_RS06165	1252399..1253316	+	918	WP_017725544.1	hypothetical protein	-
ABCAM1_RS06170	1253386..1253901	+	516	WP_017725543.1	hypothetical protein	-
ABCAM1_RS06180	1254227..1254409	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
ABCAM1_RS06185	1254502..1254906	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ABCAM1_RS06190	1255070..1255360	+	291	Protein_1183	hypothetical protein	-
ABCAM1_RS06195	1255380..1255640	-	261	WP_000124482.1	Arc family DNA-binding protein	-
ABCAM1_RS06200	1255806..1256705	+	900	WP_000096283.1	alpha/beta hydrolase	-
ABCAM1_RS06205	1257044..1257589	+	546	WP_001019718.1	N-acetylmuramidase	-
ABCAM1_RS06210	1257734..1258507	-	774	WP_001066070.1	membrane protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1220733..1288506	67773

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T140803 WP_000838146.1 NZ_CP044356:1254227-1254409 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T140803 NZ_CP059446:51032-51688 [Campylobacter fetus]
ATGAAAGAAAGCAATGAAGAACTTTTTAAAAAATTAATTGCAGACAATAAACTTGGCATAAAAGATGAAAAATTATTTGA
TAAAGAATCAAGAAAATATACTCTAGTAAGAACTAAAGAAATAATTAAAACGCCTATTAAAGGCAATTTTGATTATCAGC
ATTTGAAAAATATACATAAATATATTTTTCAAGATGTATTTCACTGGGCTGGAAAAGATAGAATGGAAGTAGGTTTGCAT
GGAAATTTTGGAAAATATGCACCAAATGGAACAATTACTAATTTTGTTCCTGGAAAAGATTTAAATGCAACCGCTCAACA
AATTTTTACTTGGCTTAAAGAAGACAATTACTTAAAAAATTCAAAAGATCTTAACGATTTTGCAAAGAACTTAGCCGAAT
TTGCTAGAAACCTAAATGCTTTGCACCCCTTTAGAGAAGGTAACGGCAGAACTCAAAGAATATTTTTAAATGAATTGACT
AAAAATGTAGGTTATAAACTTGATTTAAATTTAATACCAAAAAATAAAATGATAATGGCATCTGTAGAAGCTTCACAATT
GAAATTAGGAAAACTAGAAGCCTTAATAAAAACAAATCTAAAAAGCTTTAAGCAAAATTTAGAAAAAGAAAATACATTAG
GATTATCCTTATGTTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT140803 WP_000966688.1 NZ_CP044356:1254502-1254906 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT140803 NZ_CP059446:50800-51048 [Campylobacter fetus]
ATGACATATCCAGAAGTACATAGTTTAGAAGAAAGTTTAGCAATACTTAAAAAATATAAAGATGATGTAAGTAAAAAAGA
CTATGAAGAAATTAAATCTACCATTTGCGGACACGCTATCGAAGATATTTTTGCAAATGAAGAAGATATTATTATGCTAG
TAAAAATGAGCACATATAATCTAAGTAGTGATGAGATACTAGCAGAATACAAAGAAAAGGGATTTGTAGAATATGAAAGA
AAGCAATGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6