Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2537540..2538151 Replicon chromosome
Accession NZ_CP044352
Organism Xylella fastidiosa strain ATCC 35879

Toxin (Protein)


Gene name relE Uniprot ID Q879T9
Locus tag F7G16_RS11560 Protein ID WP_011098375.1
Coordinates 2537852..2538151 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag F7G16_RS11555 Protein ID WP_004085003.1
Coordinates 2537540..2537848 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7G16_RS11525 2534110..2534871 - 762 WP_004090267.1 Bax inhibitor-1/YccA family protein -
F7G16_RS11550 2536063..2537466 + 1404 WP_011098374.1 hypothetical protein -
F7G16_RS11555 2537540..2537848 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
F7G16_RS11560 2537852..2538151 - 300 WP_011098375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F7G16_RS11565 2538239..2538782 + 544 Protein_2216 hypothetical protein -
F7G16_RS11570 2538794..2538937 + 144 WP_155115087.1 hypothetical protein -
F7G16_RS11575 2539090..2539470 - 381 WP_004089371.1 DUF596 domain-containing protein -
F7G16_RS11580 2539475..2540605 - 1131 WP_012382788.1 DUF769 domain-containing protein -
F7G16_RS11585 2540913..2541293 - 381 WP_004087391.1 DUF596 domain-containing protein -
F7G16_RS11590 2541305..2542879 - 1575 Protein_2221 DUF637 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11378.17 Da        Isoelectric Point: 10.3861

>T140799 WP_011098375.1 NZ_CP044352:c2538151-2537852 [Xylella fastidiosa]
MTYTLKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

>T140799 NZ_CP059444:18468-19124 [Campylobacter fetus]
ATGAAAGAAAGCAATGAAGAACTTTTTAAAAAATTAATTGCAGACAATAAACTTGGCATAAAAGATGAAAAATTATTTGA
TAAAGAATCAAGAAAATATACTCTAGTAAGAACTAAAGAAATAATTAAAACGCCTATTAAAGGCAATTTTGATTATCAGC
ATTTGAAAAATATACATAAATATATTTTTCAAGATGTATTTCACTGGGCTGGAAAAGATAGAATGGAAGTAGGTTTGCAT
GGAAATTTTGGAAAATATGCACCAAATGGAACAATTACTAATTTTGTTCCTGGAAAAGATTTAAATGCAACCGCTCAACA
AATTTTTACTTGGCTTAAAGAAGACAATTACTTAAAAAATTCAAAAGATCTTAACGATTTTGCAAAGAACTTAGCCGAAT
TTGCTAGAAACCTAAATGCTTTGCACCCCTTTAGAGAAGGTAACGGCAGAACTCAAAGAATATTTTTAAATGAATTGACT
AAAAATGTAGGTTATAAACTTGATTTAAATTTAATACCAAAAAATAAAATGATAATGGCATCTGTAGAAGCTTCACAATT
GAAATTAGGAAAACTAGAAGCCTTAATAAAAACAAATCTAAAAAGCTTTAAGCAAAATTTAGAAAAAGAAAATACATTAG
GATTATCCTTATGTTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT140799 WP_004085003.1 NZ_CP044352:c2537848-2537540 [Xylella fastidiosa]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp

>AT140799 NZ_CP059444:18236-18484 [Campylobacter fetus]
ATGACATATCCAGAAGTACATAGTTTAGAAGAAAGTTTAGCAATACTTAAAAAATATAAAGATGATGTAAGTAAAAAAGA
CTATGAAGAAATTAAATCTACCATTTGCGGACACGCTATCGAAGATATTTTTGCAAATGAAGAAGATATTATTATGCTAG
TAAAAATGAGCACATATAATCTAAGTAGTGATGAGATACTAGCAGAATACAAAGAAAAGGGATTTGTAGAATATGAAAGA
AAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q879T9

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References