Detailed information of TA system TA140798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 2028583..2029114
• Replicon: chromosome
• Accession: NZ_CP044352
• Organism: Xylella fastidiosa strain ATCC 35879

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q87CH1
• Locus tag: F7G16_RS09330
• Protein ID: WP_004090909.1
• Coordinates: 2028833..2029114 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Q87CH2
• Locus tag: F7G16_RS09325
• Protein ID: WP_004090907.1
• Coordinates: 2028583..2028846 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F7G16_RS09275	2023835..2024171	-	337	Protein_1778	GPW/gp25 family protein	-
F7G16_RS09280	2024321..2024584	+	264	WP_004090907.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
F7G16_RS09285	2024571..2024852	+	282	WP_004090909.1	type II toxin-antitoxin system YafQ family toxin	-
F7G16_RS09290	2024891..2025472	-	582	Protein_1781	phage baseplate assembly protein V	-
F7G16_RS09295	2025469..2025881	-	413	Protein_1782	hypothetical protein	-
F7G16_RS09300	2025987..2026393	-	407	Protein_1783	hypothetical protein	-
F7G16_RS09305	2026393..2026644	-	252	Protein_1784	hypothetical protein	-
F7G16_RS09310	2026652..2027209	-	558	WP_004086970.1	phage tail protein I	-
F7G16_RS09315	2027202..2028095	-	894	WP_011097611.1	baseplate J/gp47 family protein	-
F7G16_RS09320	2028095..2028433	-	339	WP_004090694.1	GPW/gp25 family protein	-
F7G16_RS09325	2028583..2028846	+	264	WP_004090907.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
F7G16_RS09330	2028833..2029114	+	282	WP_004090909.1	type II toxin-antitoxin system YafQ family toxin	Toxin
F7G16_RS09335	2029151..2029743	-	593	Protein_1790	phage baseplate assembly protein V	-
F7G16_RS09340	2029740..2030282	-	543	WP_011097613.1	hypothetical protein	-
F7G16_RS09345	2030258..2030779	-	522	WP_011097614.1	hypothetical protein	-
F7G16_RS09350	2030776..2031099	-	324	WP_011097935.1	hypothetical protein	-
F7G16_RS09355	2031099..2031359	-	261	WP_038232801.1	hypothetical protein	-
F7G16_RS09360	2031377..2033251	-	1875	WP_038232803.1	phage major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2010910..2081839	70929

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10936.37 Da
• Isoelectric Point: 7.2205

>T140798 WP_004090909.1 NZ_CP044352:2028833-2029114 [Xylella fastidiosa]
MRRISQTGQFKRDYKREAKGQHRATLDEELIHVLEALTCDHPLEPRHHDHALTGDWKDHRDCHIKPDLVLIYRKPDNETL
QLVRIGSHSELGL

Nucleotide

• Length: 282 bp

>T140798 NZ_CP059442:c33870-32950 [Campylobacter fetus]
ATGCAAGAACAATATACGGAAATCAAAGATAGCAATATTATTAATAAACAAAACATAGATATTGCAGTAGGGCTTGGGCT
TGTAGATGATCTGAAGCCTTCTGAGTATTTTTATAAGGCTGTTGAAAAATCGCGAACATACAACGAACTTGAAGACAATG
TAAAGAAATATTATGATGGCAAAAAGCTAGATAAAAAAGAGGTCGGCGAAAAAGAGTGCGATATAGTTTCAGTAAATATC
GCCAAGTATTTAGAAAAAAGTGGCTTTACGCTATCTCCTGTTACATTGAAGACTATACATAAAAATTTATTTTGGGATGC
CTTTCCACAAGGGCTTGAAAAATATGTTGGAGTTTTTAGGGATGTAAATATTTCAAAAAAAGAAGAAGTCTTGGGTGGCG
AAAAAAGCGTAGAGTATGGTAATTATGATGAGCTTGGCGATATGCTGGATTATGATTTTGATAGAGAAAAACGCAAAGAT
TACGCCAAAATGACTAGGCAAGAACAGGCTTTAAATGTCGGCAAATTTGTAAGCGGGGTATGGCAAATTCATCCGTTTCG
AGAAGGCAATACTAGGACAATTGCGGTTTTTACTATTAAGTATCTGCAAAGTAAAGGCTTTGAAGCAAACAACGATATCT
TTAAAGAAAACTCAAAATATTTCAGGGATGCTTTAGTGTTAGCAAATTACGACAATATGAAAGAAAATATAAAAAGTGAT
TTTTCATACCTAGAGAGTTTTTTTAACAAATTTATTCTAAATAAAAATATAGAGTTAAAACTGCTACCAAACAGCCCAAA
AGGTCACAAAAGTGAGAAATCAGTCCTATCTAGACTTGGTGCAGCCTATGACAAAAAGGTGCAAAGTGGAGCGATCAAAC
AACCACAAATAAGCAAAAAATCAAAAGAAAAGGAAAGATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9495.95 Da
• Isoelectric Point: 5.6033

>AT140798 WP_004090907.1 NZ_CP044352:2028583-2028846 [Xylella fastidiosa]
MSANAVVRARVDAHIKEEASTVLATMGLSVSDAFRMMLTRIAREKALPFEPLVPNETTIAAMREARAGHLKSFDSIEALM
ADLHAED

Nucleotide

• Length: 264 bp

>AT140798 NZ_CP059442:c34706-33870 [Campylobacter fetus]
ATGGATGGCGGTGTAAATTTAGGCAATTTCTTAAAAAACAACAACGAGCGAGACTATTGGCTAGATGTATGTGTTCGTAT
GGCTCATCATAGCACAGCAATCGAGGGCAATACTTTAAGTCAGGATGAGACTGCTTCAATCTTGCTTGATGGCTATATAG
CAAAAGCAACTAGCGAGCGTGAATTTTATGAAGTAAAAAACTATCGCCAAATTTTGCCAAAAATGTTTTCATCTTTACAA
GAAAAAGCCAAGATAGACGAGAAGCTAATAAAAGATTTTCATAGGCTAATAATGAATAATTTAATAGACAACAACGGCAA
ATTTAAAACTATCGAAAATTTAGTTGTAGGCGCAAATTTCGAACCTACAAAGCCGTATCTAGTGCCAGTAGCAATTAAAG
ATATGTGCGATAATCTATATTTTAGACTTGATAATGCCAAAAATGACGACGATAAGCTAAAAGCAATATTGCAAAGCCAT
ATCAAATTTGAAAAAATTCATCCTTTTAGTGACGGAAACGGCAGAACCGGCAGGATAATTATGATCTATGGTTGTTTAGA
GAATAATTTAGCACCAATTATAATACCAAAAGAGCAAAAAAATAGATACATTGCAATACTGCGCAACAATGACATCGATG
GATTTATGGCGTTTGCTAAAGAAATAGAAAAAGATGAAATATCAAGGCGTAATAAATTTTTAAGCCAACGACCAAATGAG
CAAGATAATAGTAAATCAGTCTTATCTAGGCTCGGCAATGCTTACGCCAAAAAGCTAGAAAGCGGAGCGATCAAAGCATT
AAATGATACCGCAAATTCAAAGGAAAAGGAGAGATAA

Structures

Toxin

• AlphaFold DB: Q87CH1

Antitoxin

• AlphaFold DB: Q87CH2