Detailed information of TA system TA140796

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 1933369..1934165
• Replicon: chromosome
• Accession: NZ_CP044352
• Organism: Xylella fastidiosa strain ATCC 35879

Toxin (Protein)

• Gene name: VbhT
• Uniprot ID: Q87CQ8
• Locus tag: F7G16_RS08785
• Protein ID: WP_004088112.1
• Coordinates: 1933369..1933980 (-)
• Length: 204 a.a.

Antitoxin (Protein)

• Gene name: VbhA
• Uniprot ID: B2I551
• Locus tag: F7G16_RS08790
• Protein ID: WP_004088114.1
• Coordinates: 1933977..1934165 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F7G16_RS08740	1928824..1929711	-	888	WP_012382597.1	YdaU family protein	-
F7G16_RS08745	1929708..1930496	-	789	WP_011097897.1	Bro-N domain-containing protein	-
F7G16_RS08750	1930493..1931125	-	633	WP_004088094.1	Bro-N domain-containing protein	-
F7G16_RS08755	1931122..1931406	-	285	WP_004088096.1	hypothetical protein	-
F7G16_RS08760	1931403..1931651	-	249	WP_011097898.1	hypothetical protein	-
F7G16_RS08765	1931648..1931836	-	189	WP_004088102.1	hypothetical protein	-
F7G16_RS08770	1931864..1932055	-	192	WP_004088104.1	hypothetical protein	-
F7G16_RS08775	1932314..1932559	-	246	WP_004088108.1	hypothetical protein	-
F7G16_RS08780	1932644..1933318	+	675	WP_004088110.1	helix-turn-helix transcriptional regulator	-
F7G16_RS08785	1933369..1933980	-	612	WP_004088112.1	Fic/DOC family protein	Toxin
F7G16_RS08790	1933977..1934165	-	189	WP_004088114.1	antitoxin VbhA family protein	Antitoxin
F7G16_RS08795	1934557..1935093	+	537	WP_038233020.1	hypothetical protein	-
F7G16_RS08800	1935090..1935503	+	414	WP_004088056.1	DUF1566 domain-containing protein	-
F7G16_RS08805	1935500..1935901	+	402	WP_004088054.1	hypothetical protein	-
F7G16_RS08810	1935898..1936047	+	150	WP_012382602.1	hypothetical protein	-
F7G16_RS08815	1936133..1936411	+	279	WP_004088050.1	hypothetical protein	-
F7G16_RS08820	1936434..1936625	+	192	WP_012382603.1	hypothetical protein	-
F7G16_RS08825	1936646..1936990	+	345	WP_004088346.1	hypothetical protein	-
F7G16_RS08830	1937030..1937851	+	822	WP_004088345.1	DUF2303 family protein	-
F7G16_RS08835	1937867..1938793	+	927	WP_004088344.1	phage recombination protein Bet	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1903206..1943915	40709

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (55-152)

Antitoxin

• Antitoxin VbhA (10-56)

Sequences

Toxin

Protein

• Length: 204 a.a.
• Molecular weight: 22832.60 Da
• Isoelectric Point: 5.1271

>T140796 WP_004088112.1 NZ_CP044352:c1933980-1933369 [Xylella fastidiosa]
MKYAGDRGDPYLDSETGVLRNLLGIRDQGGLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKERFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVSQADMIKASIDAYNGDSSGLASIIREGISDQLFKDNE

Nucleotide

• Length: 612 bp

>T140796 NZ_CP059440:c14014-13358 [Campylobacter fetus]
ATGAAAGAAAGCAATGAAGAACTTTTTAAAAAATTAATTGCAGACAATAAACTTGGCATAAAAGATGAAAAATTATTTGA
TAAAGAATCAAGAAAATATACTCTAGTAAGAACTAAAGAAATAATTAAAACGCCTATTAAAGGCAATTTTGATTATCAGC
ATTTGAAAAATATACATAAATATATTTTTCAAGATGTATTTCACTGGGCTGGAAAAGATAGAATGGAAGTAGGTTTGCAT
GGAAATTTTGGAAAATATGCACCAAATGGAACAATTACTAATTTTGTTCCTGGAAAAGATTTAAATGCAACCGCTCAACA
AATTTTTACTTGGCTTAAAGAAGACAATTACTTAAAAAATTCAAAAGATCTTAACGATTTTGCAAAGAACTTAGCCGAAT
TTGCTAGAAACCTAAATGCTTTGCACCCCTTTAGAGAAGGTAACGGCAGAACTCAAAGAATATTTTTAAATGAATTGACT
AAAAATGTAGGTTATAAACTTGATTTAAATTTAATACCAAAAAATAAAATGATAATGGCATCTGTAGAAGCTTCACAATT
GAAATTAGGAAAACTAGAAGCCTTAATAAAAACAAATCTAAAAAGCTTTAAGCAAAATTTAGAAAAAGAAAATGCATTAG
GATTATCCTTATGTTAA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6837.77 Da
• Isoelectric Point: 4.9859

>AT140796 WP_004088114.1 NZ_CP044352:c1934165-1933977 [Xylella fastidiosa]
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIAAAVDQYKARVRLQIA

Nucleotide

• Length: 189 bp

>AT140796 NZ_CP059440:c14246-13998 [Campylobacter fetus]
ATGACATATCCAGAAGTACATAGTTTAGAAGAAAGTTTAGCAATACTTAAAAAATATAAAGATGATGTAAGTAAAAAAGA
CTATGAAGAAATTAAATCTACCATTTGCGGACACGCTATCGAAGATATTTTTGCAAATGAAGAAGATATTATTATGCTAG
TAAAAATGAGCACATATAATCTAAGTAGTGATGAGATACTAGCAGAATACAAAGAAAAGGGATTTGTAGAATATGAAAGA
AAGCAATGA

Structures

Toxin

• AlphaFold DB: Q87CQ8

Antitoxin

• AlphaFold DB: B2I551