Detailed information of TA system TA140795

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/COG3657-DUF971
• Location: 1906164..1906769
• Replicon: chromosome
• Accession: NZ_CP044352
• Organism: Xylella fastidiosa strain ATCC 35879

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: B2I5N3
• Locus tag: F7G16_RS08555
• Protein ID: WP_004089252.1
• Coordinates: 1906164..1906460 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: F7G16_RS08560
• Protein ID: WP_004089254.1
• Coordinates: 1906464..1906769 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F7G16_RS08530	1901331..1902335	-	1005	WP_072866373.1	peptidase	-
F7G16_RS08535	1902495..1902692	-	198	WP_012382581.1	hypothetical protein	-
F7G16_RS08540	1903206..1904369	-	1164	WP_038232954.1	phage tail protein	-
F7G16_RS08545	1904373..1904933	-	561	WP_014607744.1	DUF2612 domain-containing protein	-
F7G16_RS08550	1904930..1906065	-	1136	Protein_1637	baseplate J/gp47 family protein	-
F7G16_RS08555	1906164..1906460	+	297	WP_004089252.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F7G16_RS08560	1906464..1906769	+	306	WP_004089254.1	putative addiction module antidote protein	Antitoxin
F7G16_RS08565	1906780..1907133	-	354	WP_011097986.1	hypothetical protein	-
F7G16_RS08570	1907130..1907771	-	642	WP_004090764.1	hypothetical protein	-
F7G16_RS08575	1907768..1908598	-	831	WP_004090766.1	hypothetical protein	-
F7G16_RS08580	1908595..1908912	-	318	WP_011097873.1	hypothetical protein	-
F7G16_RS08585	1908912..1909682	-	771	WP_004090769.1	hypothetical protein	-
F7G16_RS08590	1909730..1910020	+	291	WP_004087089.1	hypothetical protein	-
F7G16_RS08595	1910004..1910270	+	267	WP_011097988.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1903206..1943915	40709

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-94)

Antitoxin

• Cro/C1-type helix-turn-helix domain (49-95)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10790.57 Da
• Isoelectric Point: 10.0509

>T140795 WP_004089252.1 NZ_CP044352:1906164-1906460 [Xylella fastidiosa]
MVELIKTSTFDAWINSLRDRKAAARIQARLDRLALGNPGDVKPVGAGISEMRIDHGPGYRIYFMKHGAVLILLLCGGDKS
SQVRDIEQAKALAALWKD

Nucleotide

• Length: 297 bp

>T140795 NZ_CP059440:c1487-567 [Campylobacter fetus]
ATGCAAGAACAATATACGGAAATCAAAGATAGCAATATTATTAATAAACAAAACATAGATATTGCAGTAGGGCTTGGGCT
TGTAGATGATCTGAAGCCTTCTGAGTATTTTTATAAGGCTGTTGAAAAATCGCGAACATACAACGAACTTGAAGACAATG
TAAAGAAATATTATGATGGCAAAAAGCTAGATAAAAAAGAGGTCGGCGAAAAAGAGTGCGATATAGTTTCAGTAAATATC
GCCAAGTATTTAGAAAAAAGTGGCTTTACGCTATCTCCTGTTACATTGAAGACTATACATAAAAATTTATTTTGGGATGC
CTTTCCACAAGGGCTTGAAAAATATGTTGGAGTTTTTAGGGATGTAAATATTTCAAAAAAAGAAGAAGTCTTGGGTGGCG
AAAAAAGCGTAGAGTATGGTAATTATGATGAGCTTGGCGATATGCTGGATTATGATTTTGATAGAGAAAAACGCAAAGAT
TACGCCAAAATGACTAGGCAAGAACAGGCTTTAAATGTCGGCAAATTTGTAAGCGGGGTATGGCAAATTCATCCGTTTCG
AGAAGGCAATACTAGGACAATTGCGGTTTTTACTATTAAGTATCTGCAAAGTAAAGGCTTTGAAGCAAACAACGATATCT
TTAAAGAAAACTCAAAATATTTCAGGGATGCTTTAGTGTTAGCAAATTACGACAATATGAAAGAAAATATAAAAAGTGAT
TTTTCATACCTAGAGAGTTTTTTTAACAAATTTATTCTAAATAAAAATATAGAGTTAAAACTGCTACCAAACAGCCCAAA
AGGTCACAAAAGTGAGAAATCAGTCCTATCTAGACTTGGTGCAGCCTATGACAAAAAGGTGCAAAGTGGAGCGATCAAAC
AACCACAAATAAGCAAAAAATCAAAAGAAAAGGAAAGATAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 10983.37 Da
• Isoelectric Point: 5.0941

>AT140795 WP_004089254.1 NZ_CP044352:1906464-1906769 [Xylella fastidiosa]
MNNETFSRYDTADYLKTEEDIAAYMEAVMEEGGRDNPAFIARALGAVARARNLSQLARDVGMSRQGLDKALSNDGNPSFS
TILKVAKALGLRMSFTPSSMS

Nucleotide

• Length: 306 bp

>AT140795 NZ_CP059440:c2323-1487 [Campylobacter fetus]
ATGGATGGCGGTGTAAATTTAGGCAATTTCTTAAAAAACAACAACGAGCGAGACTATTGGCTAGATGTATGTGTTCGTAT
GGCTCATCATAGCACAGCAATCGAGGGCAATACTTTAAGTCAGGATGAGACTGCTTCAATCTTGCTTGATGGCTATATAG
CAAAAGCAACTAGCGAGCGTGAATTTTATGAAGTAAAAAACTATCGCCAAATTTTGCCAAAAATGTTTTCATCTTTACAA
GAAAAAGCCAAGATAGACGAGAAGCTAATAAAAGATTTTCATAGGCTAATAATGAATAATTTAATAGACAACAACGGCAA
ATTTAAAACTATCGAAAATTTAGTTGTAGGCGCAAATTTCGAACCTACAAAGCCGTATCTAGTGCCAGTAGCAATTAAAG
ATATGTGCGATAATCTATATTTTAGACTTGATAATGCCAAAAATGACGACGATAAGCTAAAAGCAATATTGCAAAGCCAT
ATCAAATTTGAAAAAATTCATCCTTTTAGTGACGGAAACGGCAGAACCGGCAGGATAATTATGATCTATGGTTGTTTAGA
GAATAATTTAGCACCAATTATAATACCAAAAGAGCAAAAAAATAGATACATTGCAATACTGCGCAACAATGACATCGATG
GATTTATGGCGTTTGCTAAAGAAATAGAAAAAGATGAAATATCAAGGCGTAATAAATTTTTAAGCCAACGACCAAATGAG
CAAGATAATAGTAAATCAGTCTTATCTAGGCTCGGCAATGCTTACGCCAAAAAGCTAGAAAGCGGAGCGATCAAAGCATT
AAATGATACCGCAAATTCAAAGGAAAAGGAGAGATAA

Structures

Toxin

• AlphaFold DB: A0A060HBK9