Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1227324..1227910 Replicon chromosome
Accession NZ_CP044352
Organism Xylella fastidiosa strain ATCC 35879

Toxin (Protein)


Gene name hicA Uniprot ID Q87BV5
Locus tag F7G16_RS05380 Protein ID WP_004089517.1
Coordinates 1227324..1227578 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID B2I6C9
Locus tag F7G16_RS05385 Protein ID WP_004085025.1
Coordinates 1227575..1227910 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7G16_RS05345 1222827..1223432 - 606 WP_004091108.1 conjugal transfer protein TrbN -
F7G16_RS05350 1223438..1223915 - 478 Protein_1014 conjugal transfer protein -
F7G16_RS05355 1223914..1224213 + 300 WP_080513037.1 hypothetical protein -
F7G16_RS05360 1224210..1225316 + 1107 WP_012382665.1 YdaU family protein -
F7G16_RS05365 1225222..1225986 + 765 WP_004090689.1 hypothetical protein -
F7G16_RS05370 1225983..1226444 + 462 WP_011098060.1 hypothetical protein -
F7G16_RS05375 1226573..1227271 + 699 WP_011098059.1 hypothetical protein -
F7G16_RS05380 1227324..1227578 + 255 WP_004089517.1 type II toxin-antitoxin system HicA family toxin Toxin
F7G16_RS05385 1227575..1227910 + 336 WP_004085025.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F7G16_RS05390 1228090..1228389 - 300 WP_004089519.1 HigA family addiction module antidote protein -
F7G16_RS05395 1228399..1228680 - 282 WP_011098058.1 type II toxin-antitoxin system RelE/ParE family toxin -
F7G16_RS05400 1229031..1229744 + 714 WP_011098057.1 site-specific DNA-methyltransferase -
F7G16_RS05405 1229731..1230195 - 465 WP_011098056.1 low molecular weight phosphotyrosine protein phosphatase -
F7G16_RS05410 1230192..1230965 - 774 WP_004089528.1 3-deoxy-manno-octulosonate cytidylyltransferase -
F7G16_RS05415 1231457..1232311 + 855 WP_011098055.1 iron-sulfur cluster carrier protein ApbC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-80)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9639.14 Da        Isoelectric Point: 11.2766

>T140794 WP_004089517.1 NZ_CP044352:1227324-1227578 [Xylella fastidiosa]
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRMLVRLFGERRIFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Download         Length: 255 bp

>T140794 NZ_CP059438:22479-23399 [Campylobacter fetus]
ATGCAAGAACAATATACGGAAATCAAAGATAGCAATATTATTAATAAACAAAACATAGATATTGCAGTAGGGCTTGGGCT
TGTAGATGATCTGAAGCCTTCTGAGTATTTTTATAAGGCTGTTGAAAAATCGCGAACATACAACGAACTTGAAGACAATG
TAAAGAAATATTATGATGGCAAAAAGCTAGATAAAAAAGAGGTCGGCGAAAAAGAGTGCGATATAGTTTCAGTAAATATC
GCCAAGTATTTAGAAAAAAGTGGCTTTACGCTATCTCCTGTTACATTGAAGACTATACATAAAAATTTATTTTGGGATGC
CTTTCCACAAGGGCTTGAAAAATATGTTGGAGTTTTTAGGGATGTAAATATTTCAAAAAAAGAAGAAGTCTTGGGTGGCG
AAAAAAGCGTAGAGTATGGTAATTATGATGAGCTTGGCGATATGCTGGATTATGATTTTGATAGAGAAAAACGCAAAGAT
TACGCCAAAATGACTAGGCAAGAACAGGCTTTAAATGTCGGCAAATTTGTAAGCGGGGTATGGCAAATTCATCCGTTTCG
AGAAGGCAATACTAGGACAATTGCGGTTTTTACTATTAAGTATCTGCAAAGTAAAGGCTTTGAAGCAAACAACGATATCT
TTAAAGAAAACTCAAAATATTTCAGGGATGCTTTAGTGTTAGCAAATTACGACAATATGAAAGAAAATATAAAAAGTGAT
TTTTCATACCTAGAGAGTTTTTTTAACAAATTTATTCTAAATAAAAATATAGAGTTAAAACTGCTACCAAACAGCCCAAA
AGGTCACAAAAGTGAGAAATCAGTCCTATCTAGACTTGGTGCAGCCTATGACAAAAAGGTGCAAAGTGGAGCGATCAAAC
AACCACAAATAAGCAAAAAATCAAAAGAAAAGGAAAGATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12324.07 Da        Isoelectric Point: 5.6556

>AT140794 WP_004085025.1 NZ_CP044352:1227575-1227910 [Xylella fastidiosa]
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT

Download         Length: 336 bp

>AT140794 NZ_CP059438:21643-22479 [Campylobacter fetus]
ATGGATGGCGGTGTAAATTTAGGCAATTTCTTAAAAAACAACAACGAGCGAGACTATTGGCTAGATGTATGTGTTCGTAT
GGCTCATCATAGCACAGCAATCGAGGGCAATACTTTAAGTCAGGATGAGACTGCTTCAATCTTGCTTGATGGCTATATAG
CAAAAGCAACTAGCGAGCGTGAATTTTATGAAGTAAAAAACTATCGCCAAATTTTGCCAAAAATGTTTTCATCTTTACAA
GAAAAAGCCAAGATAGACGAGAAGCTAATAAAAGATTTTCATAGGCTAATAATGAATAATTTAATAGACAACAACGGCAA
ATTTAAAACTATCGAAAATTTAGTTGTAGGCGCAAATTTCGAACCTACAAAGCCGTATCTAGTGCCAGTAGCAATTAAAG
ATATGTGCGATAATCTATATTTTAGACTTGATAATGCCAAAAATGACGACGATAAGCTAAAAGCAATATTGCAAAGCCAT
ATCAAATTTGAAAAAATTCATCCTTTTAGTGACGGAAACGGCAGAACCGGCAGGATAATTATGATCTATGGTTGTTTAGA
GAATAATTTAGCACCAATTATAATACCAAAAGAGCAAAAAAATAGATACATTGCAATACTGCGCAACAATGACATCGATG
GATTTATGGCGTTTGCTAAAGAAATAGAAAAAGATGAAATATCAAGGCGTAATAAATTTTTAAGCCAACGACCAAATGAG
CAAGATAATAGTAAATCAGTCTTATCTAGGCTCGGCAATGCTTACGCCAAAAAGCTAGAAAGCGGAGCGATCAAAGCATT
AAATGATACCGCAAATTCAAAGGAAAAGGAGAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q87BV5

Antitoxin

Source ID Structure
AlphaFold DB A0A060HAK5

References