Detailed information of TA system TA140786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 4155222..4155910
• Replicon: chromosome
• Accession: NZ_CP044345
• Organism: Mycobacterium tuberculosis strain L

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: F6W99_RS20350
• Protein ID: WP_003406304.1
• Coordinates: 4155479..4155910 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: F6W99_RS20345
• Protein ID: WP_064314213.1
• Coordinates: 4155222..4155482 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F6W99_RS20325	4150799..4151623	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
F6W99_RS20330	4151628..4152809	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
F6W99_RS20335	4152886..4153986	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
F6W99_RS20340	4154157..4155146	+	990	WP_003406301.1	malate dehydrogenase	-
F6W99_RS20345	4155222..4155482	+	261	WP_064314213.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
F6W99_RS20350	4155479..4155910	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
F6W99_RS20355	4155933..4157621	-	1689	WP_003910308.1	PE family protein	-
F6W99_RS20365	4157801..4158661	+	861	WP_003900301.1	hypothetical protein	-
F6W99_RS20370	4158742..4159572	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
F6W99_RS20375	4159629..4159922	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
F6W99_RS20380	4159919..4160188	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T140786 WP_003406304.1 NZ_CP044345:4155479-4155910 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T140786 NZ_CP059422:c4814810-4814439 [Enterobacter hormaechei]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGGGCGCTCGCAGGCGTGGTCATGAAG
CGAAAACGGCAGCCGTGATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTCACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9875.22 Da
• Isoelectric Point: 5.7410

>AT140786 WP_064314213.1 NZ_CP044345:4155222-4155482 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRLAR

Nucleotide

• Length: 261 bp

>AT140786 NZ_CP059422:c4815055-4814813 [Enterobacter hormaechei]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAACTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: G0THR7