Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 3794605..3795578 | Replicon | chromosome |
Accession | NZ_CP044345 | ||
Organism | Mycobacterium tuberculosis strain L |
Toxin (Protein)
Gene name | tacT | Uniprot ID | O05911 |
Locus tag | F6W99_RS18545 | Protein ID | WP_003404756.1 |
Coordinates | 3795078..3795578 (+) | Length | 167 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | O05910 |
Locus tag | F6W99_RS18540 | Protein ID | WP_003898647.1 |
Coordinates | 3794605..3795081 (+) | Length | 159 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
F6W99_RS18520 | 3790452..3791723 | - | 1272 | WP_003404747.1 | PPE family protein | - |
F6W99_RS18525 | 3791738..3792037 | - | 300 | WP_003404748.1 | PE family protein | - |
F6W99_RS18530 | 3792481..3794262 | + | 1782 | WP_003404749.1 | BCCT family transporter | - |
F6W99_RS18535 | 3794259..3794516 | + | 258 | WP_003404750.1 | hypothetical protein | - |
F6W99_RS18540 | 3794605..3795081 | + | 477 | WP_003898647.1 | DUF1778 domain-containing protein | Antitoxin |
F6W99_RS18545 | 3795078..3795578 | + | 501 | WP_003404756.1 | GNAT family N-acetyltransferase | Toxin |
F6W99_RS18555 | 3795891..3797210 | - | 1320 | WP_003404757.1 | IS256-like element IS1554 family transposase | - |
F6W99_RS18560 | 3797498..3798079 | + | 582 | WP_003404760.1 | IS607-like element IS1535 family transposase | - |
F6W99_RS18565 | 3798079..3799731 | + | 1653 | WP_003404761.1 | IS607 family element transposase accessory protein TnpB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 3794259..3846954 | 52695 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 167 a.a. Molecular weight: 18048.55 Da Isoelectric Point: 7.8659
>T140782 WP_003404756.1 NZ_CP044345:3795078-3795578 [Mycobacterium tuberculosis]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
Download Length: 501 bp
>T140782 NZ_CP059422:c1925043-1924864 [Enterobacter hormaechei]
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTAGTGAGAGTTAAAGGCAGTCATCACCAGTT
CAAACACCCAACGAAAAAGGGGCTGGTAACGGTAAAGCATCCACAGAAAGACATACCGTTACCAACACTGAAAAGCATCA
AAAAACAGGCGGGGCTCTAA
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTAGTGAGAGTTAAAGGCAGTCATCACCAGTT
CAAACACCCAACGAAAAAGGGGCTGGTAACGGTAAAGCATCCACAGAAAGACATACCGTTACCAACACTGAAAAGCATCA
AAAAACAGGCGGGGCTCTAA
Antitoxin
Download Length: 159 a.a. Molecular weight: 17387.98 Da Isoelectric Point: 11.2467
>AT140782 WP_003898647.1 NZ_CP044345:3794605-3795081 [Mycobacterium tuberculosis]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGSSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGSSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
Download Length: 477 bp
>AT140782 NZ_CP059422:c1924842-1924432 [Enterobacter hormaechei]
ATGTTGTACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTCTCTGG
CGGTGATGATTATCAGGACGCGATCGAAAGCGTACGTGAAGCGATCGAGGCACACATCGAATTACTGGTTGAAGATGGCG
AGAGCGTTCCGGAAGCAACGACCGTCGAAAACTGGCTATCTGATCCGGAATACACCGGTGCGGTATGGGCCCTGGTTGAC
GTGGATATAACTCGCCTGATGGGAAAAGCGGAAAAAATCAATGTGACGCTTCCCTCATTGCTGATCCGCCGTATCGATCA
GTTTGTGGCCGCGCATCCAGAATACGGCAGTCGGTCTGGCTTCCTGTCTCGTGTCGCGGCAGATAAAGTAATCGGACGAG
AAAAACGATAA
ATGTTGTACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTCTCTGG
CGGTGATGATTATCAGGACGCGATCGAAAGCGTACGTGAAGCGATCGAGGCACACATCGAATTACTGGTTGAAGATGGCG
AGAGCGTTCCGGAAGCAACGACCGTCGAAAACTGGCTATCTGATCCGGAATACACCGGTGCGGTATGGGCCCTGGTTGAC
GTGGATATAACTCGCCTGATGGGAAAAGCGGAAAAAATCAATGTGACGCTTCCCTCATTGCTGATCCGCCGTATCGATCA
GTTTGTGGCCGCGCATCCAGAATACGGCAGTCGGTCTGGCTTCCTGTCTCGTGTCGCGGCAGATAAAGTAATCGGACGAG
AAAAACGATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BSZ2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A5U0V8 |