Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 3525303..3526095 Replicon chromosome
Accession NZ_CP044345
Organism Mycobacterium tuberculosis strain L

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag F6W99_RS17095 Protein ID WP_003403386.1
Coordinates 3525658..3526095 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag F6W99_RS17090 Protein ID WP_003403381.1
Coordinates 3525303..3525548 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W99_RS17060 3520323..3521828 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
F6W99_RS17065 3521909..3522919 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
F6W99_RS17070 3523307..3523690 - 384 WP_003912919.1 ribonuclease VapC6 -
F6W99_RS17075 3523785..3523940 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
F6W99_RS17080 3524016..3524732 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
F6W99_RS17085 3525008..3525316 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
F6W99_RS17090 3525303..3525548 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
F6W99_RS17095 3525658..3526095 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
F6W99_RS17100 3526092..3526346 - 255 WP_003911263.1 antitoxin VapB7 -
F6W99_RS17105 3526460..3528823 + 2364 WP_003898547.1 arylsulfatase AtsD -
F6W99_RS17110 3528886..3529212 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
F6W99_RS17115 3529124..3529462 + 339 WP_003403405.1 PIN domain-containing protein -
F6W99_RS17120 3529459..3529632 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T140778 WP_003403386.1 NZ_CP044345:c3526095-3525658 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T140778 NZ_CP059422:c333603-333301 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGGATCTATTTTAAGGACCAGGGCAATAGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT140778 WP_003403381.1 NZ_CP044345:c3525548-3525303 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT140778 NZ_CP059422:c333294-333007 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGCTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References