Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3486200..3486849 Replicon chromosome
Accession NZ_CP044345
Organism Mycobacterium tuberculosis strain L

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag F6W99_RS16885 Protein ID WP_003403236.1
Coordinates 3486454..3486849 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag F6W99_RS16880 Protein ID WP_003403235.1
Coordinates 3486200..3486454 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W99_RS21760 3481326..3482021 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
F6W99_RS21765 3482018..3482509 + 492 WP_012054156.1 galactose-1-phosphate uridylyltransferase -
F6W99_RS16860 3482506..3483597 + 1092 WP_003906403.1 galactokinase -
F6W99_RS16870 3483992..3485056 + 1065 WP_003898532.1 hypothetical protein -
F6W99_RS16875 3485160..3486107 + 948 WP_003403232.1 DUF732 domain-containing protein -
F6W99_RS16880 3486200..3486454 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
F6W99_RS16885 3486454..3486849 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
F6W99_RS16890 3486943..3487683 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
F6W99_RS16895 3487815..3488075 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
F6W99_RS16900 3488072..3488479 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
F6W99_RS16905 3488551..3489702 - 1152 WP_003403248.1 FIST C-terminal domain-containing protein -
F6W99_RS16910 3489795..3491522 - 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T140774 WP_003403236.1 NZ_CP044345:3486454-3486849 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T140774 NZ_CP059419:c3884348-3883938 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCATGGGCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT140774 WP_003403235.1 NZ_CP044345:3486200-3486454 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT140774 NZ_CP059419:c3884595-3884329 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References