Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3480572..3481197 Replicon chromosome
Accession NZ_CP044345
Organism Mycobacterium tuberculosis strain L

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag F6W99_RS16850 Protein ID WP_003403218.1
Coordinates 3480796..3481197 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag F6W99_RS16845 Protein ID WP_003403213.1
Coordinates 3480572..3480799 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W99_RS16815 3475751..3475972 - 222 WP_003898525.1 DUF4926 domain-containing protein -
F6W99_RS16820 3476114..3476719 + 606 WP_003898526.1 hypothetical protein -
F6W99_RS16825 3476738..3479305 - 2568 WP_003900188.1 SEC-C domain-containing protein -
F6W99_RS16830 3479389..3480138 + 750 WP_003898528.1 hypothetical protein -
F6W99_RS16835 3480135..3480377 + 243 WP_003403210.1 hypothetical protein -
F6W99_RS16845 3480572..3480799 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
F6W99_RS16850 3480796..3481197 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
F6W99_RS21760 3481326..3482021 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
F6W99_RS21765 3482018..3482509 + 492 WP_012054156.1 galactose-1-phosphate uridylyltransferase -
F6W99_RS16860 3482506..3483597 + 1092 WP_003906403.1 galactokinase -
F6W99_RS16870 3483992..3485056 + 1065 WP_003898532.1 hypothetical protein -
F6W99_RS16875 3485160..3486107 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T140773 WP_003403218.1 NZ_CP044345:3480796-3481197 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T140773 NZ_CP059419:3662029-3662358 [Enterobacter hormaechei]
ATGAAAACTCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTGAC
ACGCCTACTGGAACAGCATTATGGCCTGATGCTAAACGACACGCCGTTCAGTAATGAAACCACCATCCGGGAACATATTG
ATGCCGGAGTATCGCTCAGCGATGCGGTGAACTTTCTGGTAGAAAAATATGGACTTGTTCGTATCGACCGGAAGGGATTT
TCATGGCAAGAGCAAACTCCGTATATTTGCGCAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTGA
TGTGAAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT140773 WP_003403213.1 NZ_CP044345:3480572-3480799 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT140773 NZ_CP059419:3661691-3662002 [Enterobacter hormaechei]
ATGAGCAACATCACATGGGGCCTGCAGCGGGATATCACGCCACGCCTGGGAGCCCGTCTGGTGCAGGAGAGGAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGCTAAGTTTAGTGACGACGAATGCCTGAGGTTGGATGAAACATTCCCTC
ACTTTATCAGCCAGATGGAATTCATGTTGACCACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTCACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCCACGTATACATCGCCATTTATCCCACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References