140772

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3473034..3473677 Replicon chromosome
Accession NZ_CP044345
Organism Mycobacterium tuberculosis strain L

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag F6W99_RS16785 Protein ID WP_003403187.1
Coordinates 3473276..3473677 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag F6W99_RS16780 Protein ID WP_003403184.1
Coordinates 3473034..3473279 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W99_RS16745 3468314..3468784 - 471 WP_003403144.1 HAMP domain-containing protein -
F6W99_RS16750 3468828..3469589 - 762 WP_003403148.1 two-component system response regulator TcrA -
F6W99_RS16755 3469646..3469957 + 312 WP_003403164.1 hypothetical protein -
F6W99_RS16760 3470029..3470979 + 951 WP_003900184.1 DUF1259 domain-containing protein -
F6W99_RS16765 3471220..3471804 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
F6W99_RS16770 3471806..3472549 + 744 WP_003403177.1 IS607 family element transposase accessory protein TnpB -
F6W99_RS16775 3472603..3472989 + 387 WP_003403180.1 hypothetical protein -
F6W99_RS16780 3473034..3473279 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
F6W99_RS16785 3473276..3473677 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
F6W99_RS16790 3473620..3473847 + 228 WP_003900974.1 hypothetical protein -
F6W99_RS16800 3474065..3474232 - 168 WP_077385191.1 DUF3800 domain-containing protein -
F6W99_RS16805 3474265..3474462 - 198 WP_003403191.1 hypothetical protein -
F6W99_RS16810 3474542..3475699 - 1158 WP_003912926.1 hypothetical protein -
F6W99_RS16815 3475751..3475972 - 222 WP_003898525.1 DUF4926 domain-containing protein -
F6W99_RS16820 3476114..3476719 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T140772 WP_003403187.1 NZ_CP044345:3473276-3473677 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T140772 NZ_CP059419:c2859295-2859192 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT140772 WP_003403184.1 NZ_CP044345:3473034-3473279 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT140772 NZ_CP059419:2859187-2859388 [Enterobacter hormaechei]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTAAAAGTGGT
CTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References