Detailed information of TA system TA140771

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/AbrB(antitoxin)
• Location: 3466944..3467590
• Replicon: chromosome
• Accession: NZ_CP044345
• Organism: Mycobacterium tuberculosis strain L

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ88
• Locus tag: F6W99_RS16730
• Protein ID: WP_003403137.1
• Coordinates: 3466944..3467357 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ89
• Locus tag: F6W99_RS16735
• Protein ID: WP_003403139.1
• Coordinates: 3467354..3467590 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F6W99_RS16710	3463027..3464577	+	1551	WP_003403119.1	MCE family protein	-
F6W99_RS16715	3464629..3465021	-	393	WP_003403122.1	type II toxin-antitoxin system toxin ribonuclease C4	-
F6W99_RS16720	3465018..3465275	-	258	WP_003403125.1	type II toxin-antitoxin system antitoxin VapB4	-
F6W99_RS16725	3465458..3466693	-	1236	WP_003403128.1	ATP-binding protein	-
F6W99_RS16730	3466944..3467357	-	414	WP_003403137.1	type II toxin-antitoxin system VapC family toxin	Toxin
F6W99_RS16735	3467354..3467590	-	237	WP_003403139.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
F6W99_RS16740	3467694..3468200	-	507	WP_003900973.1	two component system sensor kinase HK1	-
F6W99_RS16745	3468314..3468784	-	471	WP_003403144.1	HAMP domain-containing protein	-
F6W99_RS16750	3468828..3469589	-	762	WP_003403148.1	two-component system response regulator TcrA	-
F6W99_RS16755	3469646..3469957	+	312	WP_003403164.1	hypothetical protein	-
F6W99_RS16760	3470029..3470979	+	951	WP_003900184.1	DUF1259 domain-containing protein	-
F6W99_RS16765	3471220..3471804	+	585	WP_003403171.1	IS607-like element IS1536 family transposase	-
F6W99_RS16770	3471806..3472549	+	744	WP_003403177.1	IS607 family element transposase accessory protein TnpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-126)

Antitoxin

• SpoVT-AbrB domain (3-43)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 14786.14 Da
• Isoelectric Point: 8.1405

>T140771 WP_003403137.1 NZ_CP044345:c3467357-3466944 [Mycobacterium tuberculosis]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA

Nucleotide

• Length: 414 bp

>T140771 NZ_CP059419:c2421228-2420743 [Enterobacter hormaechei]
GTGGGACGTGTAACCGCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTGCTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACCA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATT
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATAATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8212.41 Da
• Isoelectric Point: 5.0351

>AT140771 WP_003403139.1 NZ_CP044345:c3467590-3467354 [Mycobacterium tuberculosis]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK

Nucleotide

• Length: 237 bp

>AT140771 NZ_CP059419:c2421482-2421216 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Toxin

• AlphaFold DB: G0TQ88

Antitoxin

• AlphaFold DB: G0TQ89