Detailed information of TA system TA140764

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 3131634..3132160
• Replicon: chromosome
• Accession: NZ_CP044345
• Organism: Mycobacterium tuberculosis strain L

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: F6W99_RS15130
• Protein ID: WP_003401560.1
• Coordinates: 3131858..3132160 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: P9WJ08
• Locus tag: F6W99_RS15125
• Protein ID: WP_003401555.1
• Coordinates: 3131634..3131861 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F6W99_RS15110	3127327..3128130	-	804	WP_003401540.1	hypothetical protein	-
F6W99_RS15115	3128140..3129537	-	1398	WP_003914582.1	sulfatase	-
F6W99_RS15120	3129716..3131491	+	1776	WP_010886074.1	PE family protein	-
F6W99_RS15125	3131634..3131861	+	228	WP_003401555.1	ribbon-helix-helix protein, CopG family	Antitoxin
F6W99_RS15130	3131858..3132160	+	303	WP_003401560.1	toxin-antitoxin system toxin	Toxin
F6W99_RS15135	3132208..3132429	+	222	WP_003401563.1	type II toxin-antitoxin system antitoxin VapB2	-
F6W99_RS15140	3132426..3132851	+	426	WP_003401566.1	PIN domain nuclease	-
F6W99_RS15145	3132987..3133619	+	633	WP_003401571.1	TetR/AcrR family transcriptional regulator	-
F6W99_RS15150	3133616..3134524	+	909	WP_003900117.1	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10442.16 Da
• Isoelectric Point: 4.9609

>T140764 WP_003401560.1 NZ_CP044345:3131858-3132160 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Nucleotide

• Length: 303 bp

>T140764 NZ_CP059414:4535736-4536023 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGCTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8130.21 Da
• Isoelectric Point: 7.0084

>AT140764 WP_003401555.1 NZ_CP044345:3131634-3131861 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Nucleotide

• Length: 228 bp

>AT140764 NZ_CP059414:4535427-4535729 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGGATCTATTTTAAGGACCAGGGCAATAGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4F8T1