Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 2174097..2174803 Replicon chromosome
Accession NZ_CP044345
Organism Mycobacterium tuberculosis strain L

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag F6W99_RS10645 Protein ID WP_003417998.1
Coordinates 2174393..2174803 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WF23
Locus tag F6W99_RS10640 Protein ID WP_003417995.1
Coordinates 2174097..2174396 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W99_RS10620 2170107..2171708 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
F6W99_RS10625 2171725..2172429 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
F6W99_RS10630 2172547..2173113 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
F6W99_RS10635 2173175..2174062 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
F6W99_RS10640 2174097..2174396 + 300 WP_003417995.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F6W99_RS10645 2174393..2174803 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
F6W99_RS10650 2174836..2176572 - 1737 WP_003418002.1 cholesterol oxidase -
F6W99_RS10655 2176628..2177755 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
F6W99_RS10660 2177775..2179364 - 1590 WP_003900682.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-61)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T140761 WP_003417998.1 NZ_CP044345:2174393-2174803 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

>T140761 NZ_CP059414:3220107-3220580 [Enterobacter hormaechei]
ATGATTTTTTATCGTCTGGTGACAGGACGTTTTGCCAGCGAAGCGTGGAGTGGCAGTGGTGCAAACCAGTATGGCGGACG
CTGGAATCATAAAGGCCATCCTGCCGTGTATGTCTCCACCTCCATCTCGCTAGCTTCACTGGAAATTCTGGTGCACGTCA
GAAAAGACACCGTGCTGAACCAGTACCAGCTTTTCAGCATTGATATCCCGGATGACCAGATTGATTACCTGGATAAAGCG
TGGCTGCCCGAGGACTGGCAGGAAAATCCGGCGCCCGTATCAACGATGGATCTGGGTACCGGTTGGTTGCAGGCTAACAG
CGCTCTCGCACTCATCTTACCCTCCTGCATCATTCCCTATGAAAACAACGCCATACTTAATCCATTGCATCCGGCATTCC
ACAAAGCACTCAATTCTGTTGAATTAATGCCTTTTAATTTTGATACCCGTCTCGCAGAAAAAACCGCACCCTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11009.66 Da        Isoelectric Point: 10.7399

>AT140761 WP_003417995.1 NZ_CP044345:2174097-2174396 [Mycobacterium tuberculosis]
MRATVGLVEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEP
ARGRKRTLSDVLNEMRDEQ

Download         Length: 300 bp

>AT140761 NZ_CP059414:3219667-3220110 [Enterobacter hormaechei]
ATGAGAACATGGGTTCCTGCGCAAAGGCCGGCTGATAACACGCTGTGGCGCTACGCCGGTTTGCCTGCAAGCAGAGGCAT
GCGGCTGATAGAATATCTCAATCAAGGATTACCCGTCAGCGTCCTCGACAATATTCACGAGTGGACGGACATGTCGAAAG
CGGAGATTTTACGCGTCACGGGAATCAACGAGCGTAACGTTGCCCGCCGCAAAAGTACGGGCCGGACGCTGACGCCCGAC
GAGAGCGAACGTGTGGCGCGTTTCGTTCGGGTACTTGATGCGGCTGTCGATTATTTCGGCAGTAAAGAAGAGGCATGGAA
CTGGTTGCAGTTACCGGTACGTGGGCTTGGCAATGTTGCGCCTGTCGATCTGATCGCCACGGAAACCGGTGCGCTGGAAG
TTACCGATTTGATTGGTCGGCTGGAGCACGGAGTGTTCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure
AlphaFold DB A0A045H9T3

References