Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/Txe-YefM |
Location | 2119554..2120083 | Replicon | chromosome |
Accession | NZ_CP044345 | ||
Organism | Mycobacterium tuberculosis strain L |
Toxin (Protein)
Gene name | relE | Uniprot ID | G0TI95 |
Locus tag | F6W99_RS10375 | Protein ID | WP_003417760.1 |
Coordinates | 2119826..2120083 (+) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | G0TI94 |
Locus tag | F6W99_RS10370 | Protein ID | WP_003417757.1 |
Coordinates | 2119554..2119829 (+) | Length | 92 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
F6W99_RS10335 | 2116127..2116921 | - | 795 | WP_003417738.1 | BBE domain-containing protein | - |
F6W99_RS10340 | 2117003..2117374 | - | 372 | WP_003417739.1 | FAD-binding oxidoreductase | - |
F6W99_RS21680 | 2117272..2117490 | - | 219 | WP_157132559.1 | hypothetical protein | - |
F6W99_RS10350 | 2117517..2117780 | - | 264 | WP_003906084.1 | hypothetical protein | - |
F6W99_RS10355 | 2117892..2118281 | + | 390 | WP_003417745.1 | DUF732 domain-containing protein | - |
F6W99_RS10360 | 2118295..2118588 | - | 294 | WP_003417749.1 | DUF3017 domain-containing protein | - |
F6W99_RS10365 | 2118585..2119430 | - | 846 | WP_003417751.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | - |
F6W99_RS10370 | 2119554..2119829 | + | 276 | WP_003417757.1 | type II toxin-antitoxin system antitoxin RelJ | Antitoxin |
F6W99_RS10375 | 2119826..2120083 | + | 258 | WP_003417760.1 | Txe/YoeB family addiction module toxin | Toxin |
F6W99_RS10380 | 2120125..2121315 | + | 1191 | WP_003900033.1 | NADH:flavin oxidoreductase | - |
F6W99_RS10385 | 2121432..2121800 | + | 369 | WP_003417765.1 | FHA domain-containing protein | - |
F6W99_RS10390 | 2121797..2122348 | - | 552 | WP_003417767.1 | pentapeptide repeat protein MfpA | - |
F6W99_RS10395 | 2122355..2122936 | - | 582 | WP_003417769.1 | ATP/GTP-binding protein | - |
F6W99_RS10400 | 2122917..2123285 | - | 369 | WP_003417772.1 | DUF742 domain-containing protein | - |
F6W99_RS10405 | 2123263..2123655 | - | 393 | WP_003417776.1 | roadblock/LC7 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10070.30 Da Isoelectric Point: 6.4693
>T140759 WP_003417760.1 NZ_CP044345:2119826-2120083 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
Download Length: 258 bp
>T140759 NZ_CP059414:2943989-2944168 [Enterobacter hormaechei]
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTAGTGAGAGTTAAAGGCAGTCATCACCAGTT
CAAACACCCAACGAAAAAGGGGCTGGTAACGGTAAAGCATCCACAGAAAGACATACCGTTACCAACACTGAAAAGCATCA
AAAAACAGGCGGGGCTCTAA
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTAGTGAGAGTTAAAGGCAGTCATCACCAGTT
CAAACACCCAACGAAAAAGGGGCTGGTAACGGTAAAGCATCCACAGAAAGACATACCGTTACCAACACTGAAAAGCATCA
AAAAACAGGCGGGGCTCTAA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10194.35 Da Isoelectric Point: 4.6652
>AT140759 WP_003417757.1 NZ_CP044345:2119554-2119829 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
Download Length: 276 bp
>AT140759 NZ_CP059414:2944190-2944600 [Enterobacter hormaechei]
ATGTTGTACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTCTCTGG
CGGTGATGATTATCAGGACGCGATCGAAAGCGTACGTGAAGCGATCGAGGCACACATCGAATTACTGGTTGAAGATGGCG
AGAGCGTTCCGGAAGCAACGACCGTCGAAAACTGGCTATCTGATCCGGAATACACCGGTGCGGTATGGGCCCTGGTTGAC
GTGGATATAACTCGCCTGATGGGAAAAGCGGAAAAAATCAATGTGACGCTTCCCTCATTGCTGATCCGCCGTATCGATCA
GTTTGTGGCCGCGCATCCAGAATACGGCAGTCGGTCTGGCTTCCTGTCTCGTGTCGCGGCAGATAAAGTAATCGGACGAG
AAAAACGATAA
ATGTTGTACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTCTCTGG
CGGTGATGATTATCAGGACGCGATCGAAAGCGTACGTGAAGCGATCGAGGCACACATCGAATTACTGGTTGAAGATGGCG
AGAGCGTTCCGGAAGCAACGACCGTCGAAAACTGGCTATCTGATCCGGAATACACCGGTGCGGTATGGGCCCTGGTTGAC
GTGGATATAACTCGCCTGATGGGAAAAGCGGAAAAAATCAATGTGACGCTTCCCTCATTGCTGATCCGCCGTATCGATCA
GTTTGTGGCCGCGCATCCAGAATACGGCAGTCGGTCTGGCTTCCTGTCTCGTGTCGCGGCAGATAAAGTAATCGGACGAG
AAAAACGATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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