Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2050599..2051273 Replicon chromosome
Accession NZ_CP044345
Organism Mycobacterium tuberculosis strain L

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag F6W99_RS10140 Protein ID WP_003417282.1
Coordinates 2050599..2051027 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag F6W99_RS10145 Protein ID WP_003417286.1
Coordinates 2051031..2051273 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W99_RS10115 2046420..2046821 - 402 WP_003417264.1 cytidine deaminase -
F6W99_RS10120 2046962..2047396 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
F6W99_RS10125 2047393..2047827 + 435 WP_003913036.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
F6W99_RS10130 2047958..2049729 + 1772 Protein_1920 succinate dehydrogenase flavoprotein subunit -
F6W99_RS10135 2049729..2050520 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
F6W99_RS10140 2050599..2051027 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
F6W99_RS10145 2051031..2051273 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
F6W99_RS10150 2051395..2052009 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
F6W99_RS10155 2052006..2052671 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
F6W99_RS10160 2052672..2053205 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
F6W99_RS10165 2053202..2053576 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
F6W99_RS10170 2053673..2054737 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T140758 WP_003417282.1 NZ_CP044345:c2051027-2050599 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T140758 NZ_CP059414:c2858834-2858731 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT140758 WP_003417286.1 NZ_CP044345:c2051273-2051031 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT140758 NZ_CP059414:2858718-2858927 [Enterobacter hormaechei]
TTTTCAAGCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTA
AAAGTGGTCTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAGCCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References