Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1280736..1281450 Replicon chromosome
Accession NZ_CP044345
Organism Mycobacterium tuberculosis strain L

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag F6W99_RS06235 Protein ID WP_003413460.1
Coordinates 1281010..1281450 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag F6W99_RS06230 Protein ID WP_003413456.1
Coordinates 1280736..1281023 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W99_RS06195 1276158..1276403 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
F6W99_RS06200 1276400..1276804 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
F6W99_RS06205 1277021..1277641 + 621 WP_003912795.1 DUF4178 domain-containing protein -
F6W99_RS06210 1277652..1278146 + 495 WP_003413444.1 DUF2617 family protein -
F6W99_RS06215 1278143..1278574 + 432 WP_003899390.1 DUF4247 domain-containing protein -
F6W99_RS06220 1278656..1279057 + 402 WP_003899391.1 DUF350 domain-containing protein -
F6W99_RS06225 1279054..1280625 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
F6W99_RS06230 1280736..1281023 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
F6W99_RS06235 1281010..1281450 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
F6W99_RS06240 1281471..1282226 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
F6W99_RS06245 1282359..1282955 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
F6W99_RS06250 1282963..1283808 - 846 WP_003413466.1 acyl-CoA thioesterase II -
F6W99_RS06255 1283837..1284736 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
F6W99_RS06260 1284864..1285538 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T140749 WP_003413460.1 NZ_CP044345:1281010-1281450 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T140749 NZ_CP059400:2607659-2608966 [Legionella sp. PC1000]
ATGGTAAAGAAAAATCAAATTCTTTATGTCCTAATGAATGGAATTTTGGTGGGAATGCTTGAGAAAACATCTCAGGGAGG
ATTGAGGTTTACTTATCATCAAGACTGGTTAAATCAAACAGGAGCCCGCCCCATTTCCTTATCATTACCGCTCGTTGAAC
AAACCTATGCTGGCGATGTAGTATATAATTTTTTTGATAATCTGCTCCCTGATAATCAACAAATCCGCGCACGAATACAA
GCACGATTTCAAATAGCAACCAGCCAACCTTTTGATCTGCTGGCGGGTATCGGCAGGGATTGTGTAGGAGCCATTCAGCT
CATTACAGGTCCATTGGCTGAATTTGAGAAAAAAATTAAATATAAGCCATTAACAGAGCAAAAAATCGCTTCAATTTTAC
GAAATTATCAAATAAATCCCCTAGGGATGAGTCTAGAAGAAAAGGACTTCCGAATTTCTATTGCGGGGGCTCAAGAAAAA
ACTGCTTTTTTATATCATGAAAACCAATGGTGCGAGCCGCTTCAAGAAACGCCAACCACACATATTTTTAAATTACCCAT
TGGCATTATCGCTCACCAACAGATGGATTTACGAGACAGTTGTGAGAACGAATGGCTGTGCTCTCTTCTTGCAAAAAGCT
ATGGATTACCGGCAGCCGACTGTGAGATTCTGCATTTTGAAGAGATAAAGGTTTTATCAGTAAAACGCTTTGATCGCAGG
TTATCTCGGGATAAAAGTTGGATCATGCGTTTACCTCAAGAGGACCTATGTCAAGCATTAGGCGTTTCTTACAACATCAA
ATATCAATCGGATGGTGGCCCTGGTATTAAAGAAATTATGCAAGTATTGCTCGGTTCAGCACACCCGCTTTTAGACCGCG
ATATGTTTTATCGTGCTCAGGTTTTTTTCTGGCTCATTGCTGGGATTGATGGCCATGCTAAAAATTTCAGTCTTTTTATT
GAGCCTGAAGGAAAGTACAGACTAACACCTCTATACGACATCATGTCTGCATATCCGCTGATAAAGAAAAGGCAACTACA
AATTCAGAAAATTAAAATGGCAATGGCCTTAAAAGGTAAAAACAATCATTATCACTGGCATACCCTCCAACGACGGCATT
TTATAGACACCGCAAAAGAAACAAGTTACTCTCCAGAAAGAGCTGAAATCATCCTTAATGAAATGCTGGAACAAACAGAT
TCTGTTATCCAGGAAGTCTCAAAAAAACTCCCTTCCTCCTTCCCTAACAGTATTTCTGAACCTATATTCGAAGGATTACG
AAAAACAAAACAAAAATTAGAACAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT140749 WP_003413456.1 NZ_CP044345:1280736-1281023 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT140749 NZ_CP059400:2607414-2607665 [Legionella sp. PC1000]
ATGCTGATTCACTCTTCTCTGGAGCTGGCGTTGTTGATAAAAAATCAACGAAAAAAACTGAAATTAAGCCAGGCAGAAGT
TGCTGCTTTGGTAGGTTTAAAACAAAAAACCATTTCCGCAATCGAAAATAATCCAGAAAACATGAGATTAAGCACTTTAT
TTCGCATATTATCCGCGCTTGGTTTGGATTTAAAAATATCAGCAAAAAGTCAGTCTAATAGAGCAACTAATCAATGGAAC
GATGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References