Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
Location | 1220394..1221031 | Replicon | chromosome |
Accession | NZ_CP044345 | ||
Organism | Mycobacterium tuberculosis strain L |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P0DMV7 |
Locus tag | F6W99_RS05950 | Protein ID | WP_003413180.1 |
Coordinates | 1220394..1220789 (-) | Length | 132 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P9WJ44 |
Locus tag | F6W99_RS05955 | Protein ID | WP_003413183.1 |
Coordinates | 1220786..1221031 (-) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
F6W99_RS05905 | 1215797..1217008 | + | 1212 | WP_003900845.1 | alpha/beta hydrolase family protein | - |
F6W99_RS05915 | 1217135..1217794 | + | 660 | WP_003900846.1 | LppA family lipoprotein | - |
F6W99_RS05920 | 1217791..1218453 | + | 663 | WP_003900848.1 | hypothetical protein | - |
F6W99_RS05925 | 1218450..1218728 | + | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
F6W99_RS05930 | 1218821..1219234 | + | 414 | WP_003912787.1 | PIN domain nuclease | - |
F6W99_RS05935 | 1219273..1219530 | + | 258 | WP_003413167.1 | ribbon-helix-helix domain-containing protein | - |
F6W99_RS05940 | 1219527..1219904 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | - |
F6W99_RS05945 | 1219920..1220294 | - | 375 | WP_003413177.1 | hypothetical protein | - |
F6W99_RS05950 | 1220394..1220789 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | Toxin |
F6W99_RS05955 | 1220786..1221031 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | Antitoxin |
F6W99_RS05965 | 1221442..1221861 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
F6W99_RS05970 | 1221873..1222682 | - | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
F6W99_RS05975 | 1222679..1223932 | - | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
F6W99_RS05980 | 1223925..1224437 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14619.53 Da Isoelectric Point: 6.9794
>T140748 WP_003413180.1 NZ_CP044345:c1220789-1220394 [Mycobacterium tuberculosis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE
Download Length: 396 bp
>T140748 NZ_CP059400:864707-864988 [Legionella sp. PC1000]
ATGCTTGAATTAGAATTAGCCACTCAATTTAAGCGCGATTTAAAAAAGATAGTGAAGCAGGGGAAGGATAGAAAGCTAAT
CGATTCGATTGTGGGGCAATTGCAAAGGGAAGAACCATTGCACCCAAAGCATCAAGATCATAACCTTTCTGGAAATTGGC
ATGGCTATCGTGAATGTCACATCACCCCTGATTGGCTATTAATTTATAAAGTCATTAAGGATGAGTGTATGCAGTTGCTA
AGATTATCGAGAACTGGCTCTCATTCTGATTTGTTTAAATAG
ATGCTTGAATTAGAATTAGCCACTCAATTTAAGCGCGATTTAAAAAAGATAGTGAAGCAGGGGAAGGATAGAAAGCTAAT
CGATTCGATTGTGGGGCAATTGCAAAGGGAAGAACCATTGCACCCAAAGCATCAAGATCATAACCTTTCTGGAAATTGGC
ATGGCTATCGTGAATGTCACATCACCCCTGATTGGCTATTAATTTATAAAGTCATTAAGGATGAGTGTATGCAGTTGCTA
AGATTATCGAGAACTGGCTCTCATTCTGATTTGTTTAAATAG
Antitoxin
Download Length: 82 a.a. Molecular weight: 9098.33 Da Isoelectric Point: 5.6007
>AT140748 WP_003413183.1 NZ_CP044345:c1221031-1220786 [Mycobacterium tuberculosis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E
Download Length: 246 bp
>AT140748 NZ_CP059400:864454-864714 [Legionella sp. PC1000]
ATGAGTAAGGCAGCGACAATTAATGCTCGTATTGAGCCTGCTCTTAAAATGCAGGCGGAAGCGATATTGCATAAAGTAGG
TTTATCTACAGCCGAGGCAATTCGACTGTTCTATAGTCAAGTTTGTCTTCAAAATGGTCTCCCGTTTGAGGTAAAAATAC
CGAACAAGAAGACACTTGATGCAATTAAAGAGCTTGAATCAGGTAAAGGAGAGCGATTTAAAACCATGAAGGATGTTTGG
GATTCTATAGATAATGCTTGA
ATGAGTAAGGCAGCGACAATTAATGCTCGTATTGAGCCTGCTCTTAAAATGCAGGCGGAAGCGATATTGCATAAAGTAGG
TTTATCTACAGCCGAGGCAATTCGACTGTTCTATAGTCAAGTTTGTCTTCAAAATGGTCTCCCGTTTGAGGTAAAAATAC
CGAACAAGAAGACACTTGATGCAATTAAAGAGCTTGAATCAGGTAAAGGAGAGCGATTTAAAACCATGAAGGATGTTTGG
GATTCTATAGATAATGCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 5WZ4 | |
PDB | 5WZF |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BW31 |