Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1219273..1219904 Replicon chromosome
Accession NZ_CP044345
Organism Mycobacterium tuberculosis strain L

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ28
Locus tag F6W99_RS05940 Protein ID WP_003413174.1
Coordinates 1219527..1219904 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag F6W99_RS05935 Protein ID WP_003413167.1
Coordinates 1219273..1219530 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W99_RS05900 1215186..1215501 + 316 Protein_1120 hypothetical protein -
F6W99_RS05905 1215797..1217008 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
F6W99_RS05915 1217135..1217794 + 660 WP_003900846.1 LppA family lipoprotein -
F6W99_RS05920 1217791..1218453 + 663 WP_003900848.1 hypothetical protein -
F6W99_RS05925 1218450..1218728 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
F6W99_RS05930 1218821..1219234 + 414 WP_003912787.1 PIN domain nuclease -
F6W99_RS05935 1219273..1219530 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
F6W99_RS05940 1219527..1219904 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin Toxin
F6W99_RS05945 1219920..1220294 - 375 WP_003413177.1 hypothetical protein -
F6W99_RS05950 1220394..1220789 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
F6W99_RS05955 1220786..1221031 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
F6W99_RS05965 1221442..1221861 - 420 WP_003413190.1 A24 family peptidase -
F6W99_RS05970 1221873..1222682 - 810 WP_003413193.1 shikimate dehydrogenase -
F6W99_RS05975 1222679..1223932 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
F6W99_RS05980 1223925..1224437 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13728.72 Da        Isoelectric Point: 4.4687

>T140747 WP_003413174.1 NZ_CP044345:1219527-1219904 [Mycobacterium tuberculosis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY

Download         Length: 378 bp

>T140747 NZ_CP059400:657023-657874 [Legionella sp. PC1000]
ATGACAAAAAATATTGGTGAGTCTATACGCTCGCGTTTAAAGAATATAGCTGTTAAAGAAGGTTCTGATTTTAATGCGGT
ATTGATTCGTTATGGTCTAGAGCGTTTGTTATATCGAATTGGAGAATCAGAATATTCTAAACAGTTTTTGTTGAAAGGTG
CCTTACTATTTAACCTATGGTATGACATGCCTCATCGCCCAACTAAAGATATTGATTTATTGGGGTTTGGTGATAATGAT
CTAGCGTATATTAAACAAACGTTCAGTAATATTTGCAGCATATCTGCAGATGATGGAATAAGTTTTCTGTCTGAATCAGT
GACGGTTGACACTATCAAAAAAGATGGGGGGTATACTGGAGCAAGAGTTGAGTTATTTGGGGAACTGGCGAAAGCAAAGA
TTAAAATACAAATTGATATTGGTTATGGTGATGCAGTTACTCCTGGGCCAATAGATGCCCATTATCCCGTACTTCTTACT
GATCTTCCTGCTCCTAAAATCCGTACTTATCCAATTTATACAGTAATTGCAGAAAAGCTGCACGCAATTGCATTATTGGG
CATGGCGAATAGTCGATTAAAAGACTACTTGGATCTTTATGTATTATTAGGTAATGAACAGATAGATAATCAAGTCTTGG
CTAAAGCTATACAGGCTACATTTAATCGTCGCGGTATGGATCTTCTTGAAGCGCTGCCTATTGGCCTGACCGATGAGTTT
GCTAACGACCCAAGCAGGGAGTCAATGTGGAAAGCCTTTTTGAGAAAAAATGAACTAGAGCAGAAACCATTAAGTGAAGT
TATTGCTGTGATCAGAAATTTGATTCAAGTGCCATATTCTTTGGCAAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT140747 WP_003413167.1 NZ_CP044345:1219273-1219530 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT140747 NZ_CP059400:656418-657026 [Legionella sp. PC1000]
ATGAAGACAGAAGCTACCTATAAACAAAAAGTACTCCAGATGGCTAGTAAAACGGGCATTGTTCGAATGTCCGATCTAAC
CGAAAGGGGGATCACTAGAGCGACCATTTCGAGGCTTGTTAGCGAAAACAAACTTGAAAAACTCGCTTCTGGGCTCTATT
GCTTGCCTGAGGCTGAGTTTTCAGAAAAAGAAAGCCTGGTTATTATAGCAAGCCGAGTACCTCAAGCAGTGTTTTGCCTG
CTAACTGCTTTGCAGATTCATGATCTAACAACACAGCTACCTCGAAAAGTATGGATAGCTATGCCAAAAGGGAGTCATGC
GCCAAAAATGGATTATCCTCCGCTAAAAATGGTGCAATATTCAGATGAAGCCTTTAGTGAAGGAGTTGAAATTATAGAAT
CAGATAATATTAAACTAAGGGTGTATAACCGTGCCAAGACAATTGCAGATTGTTTCAAGCATCGCAATAAAATTGGACTT
GATGTGGCCATTGAAGCGCTCAAAGAGGCTTATACAAAAAATAAAGTCACAGTTGATGAACTATGGCATTATGCGAAAAT
TTGTCGCGTTGCAAACGTAATGCGTCCTTATATTGAGGCAATTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ28

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References