Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
| Location | 1218821..1219530 | Replicon | chromosome |
| Accession | NZ_CP044345 | ||
| Organism | Mycobacterium tuberculosis strain L | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | F6W99_RS05930 | Protein ID | WP_003912787.1 |
| Coordinates | 1218821..1219234 (+) | Length | 138 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | P95006 |
| Locus tag | F6W99_RS05935 | Protein ID | WP_003413167.1 |
| Coordinates | 1219273..1219530 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| F6W99_RS05895 | 1213872..1215077 | - | 1206 | WP_003413027.1 | chorismate synthase | - |
| F6W99_RS05900 | 1215186..1215501 | + | 316 | Protein_1120 | hypothetical protein | - |
| F6W99_RS05905 | 1215797..1217008 | + | 1212 | WP_003900845.1 | alpha/beta hydrolase family protein | - |
| F6W99_RS05915 | 1217135..1217794 | + | 660 | WP_003900846.1 | LppA family lipoprotein | - |
| F6W99_RS05920 | 1217791..1218453 | + | 663 | WP_003900848.1 | hypothetical protein | - |
| F6W99_RS05925 | 1218450..1218728 | + | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| F6W99_RS05930 | 1218821..1219234 | + | 414 | WP_003912787.1 | PIN domain nuclease | Toxin |
| F6W99_RS05935 | 1219273..1219530 | + | 258 | WP_003413167.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| F6W99_RS05940 | 1219527..1219904 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | - |
| F6W99_RS05945 | 1219920..1220294 | - | 375 | WP_003413177.1 | hypothetical protein | - |
| F6W99_RS05950 | 1220394..1220789 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | - |
| F6W99_RS05955 | 1220786..1221031 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | - |
| F6W99_RS05965 | 1221442..1221861 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
| F6W99_RS05970 | 1221873..1222682 | - | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
| F6W99_RS05975 | 1222679..1223932 | - | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
| F6W99_RS05980 | 1223925..1224437 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 15044.06 Da Isoelectric Point: 6.1243
>T140746 WP_003912787.1 NZ_CP044345:1218821-1219234 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAKTFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAKTFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL
Download Length: 414 bp
>T140746 NZ_CP059399:7196303-7196668 [Nocardia sp. WCH-YHL-001]
ATGGCGGACCAGGAGTGGGATATCTACATCGTCGACGAGGTAAGGCAATGGATCGAGCGTCTCGACGAGCCGACCTTCCG
CCGCGTAGTGGAAGCCATCGACGCCCTCGCCGATGGCGGACCGGGGTTGGGTCGTCCGCTGGTCGACTCAATTGCCGGTT
CCAAGGTCTCGAATATGAAAGAGCTCCGTCCCGGAACCGTACGGATCCTTTTCGCGTTCGATCCGTGGCGGTCGAGCGTA
CTGCTCGCGGCGGGCGACAAAGTCCACCAATGGAACTCGTGGTATCAGACCGCGATTCCACTGGCGGAGCGACGATATGA
GTCCTACCTGCGCGAGCGCGGCGAGGAAGAGGAGGGATTGCGATGA
ATGGCGGACCAGGAGTGGGATATCTACATCGTCGACGAGGTAAGGCAATGGATCGAGCGTCTCGACGAGCCGACCTTCCG
CCGCGTAGTGGAAGCCATCGACGCCCTCGCCGATGGCGGACCGGGGTTGGGTCGTCCGCTGGTCGACTCAATTGCCGGTT
CCAAGGTCTCGAATATGAAAGAGCTCCGTCCCGGAACCGTACGGATCCTTTTCGCGTTCGATCCGTGGCGGTCGAGCGTA
CTGCTCGCGGCGGGCGACAAAGTCCACCAATGGAACTCGTGGTATCAGACCGCGATTCCACTGGCGGAGCGACGATATGA
GTCCTACCTGCGCGAGCGCGGCGAGGAAGAGGAGGGATTGCGATGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9453.63 Da Isoelectric Point: 10.6555
>AT140746 WP_003413167.1 NZ_CP044345:1219273-1219530 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
Download Length: 258 bp
>AT140746 NZ_CP059399:7196665-7196982 [Nocardia sp. WCH-YHL-001]
ATGAGCGGACATGTGCGTTGGCAAGACATTCGAGCCGAAATGGTGGATCGGGCAGGTGGCGAAGCTGCGGTTGCCAAGGG
GAAGGACGAACTGCTCGCTCAGGTTCGCGGACAGCGGCTCGCCGATATCCGGCGCAGACGTGGGTTGACTCAACTGCAGG
TCGCCGACCGGATGGGTGTCACGAAGGGGCGAGTTTCGCAGATCGAGCAAGGCACTGTCACCGGCCAGGAAGTTCTCGCA
CGGTATGCGCTGGCATTGGGCGGCCGACTCCATCAGTCGATCTACTTCGATGACGGGGATATCGTCGCTATCGCCTGA
ATGAGCGGACATGTGCGTTGGCAAGACATTCGAGCCGAAATGGTGGATCGGGCAGGTGGCGAAGCTGCGGTTGCCAAGGG
GAAGGACGAACTGCTCGCTCAGGTTCGCGGACAGCGGCTCGCCGATATCCGGCGCAGACGTGGGTTGACTCAACTGCAGG
TCGCCGACCGGATGGGTGTCACGAAGGGGCGAGTTTCGCAGATCGAGCAAGGCACTGTCACCGGCCAGGAAGTTCTCGCA
CGGTATGCGCTGGCATTGGGCGGCCGACTCCATCAGTCGATCTACTTCGATGACGGGGATATCGTCGCTATCGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|