Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1158825..1159477 Replicon chromosome
Accession NZ_CP044345
Organism Mycobacterium tuberculosis strain L

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag F6W99_RS05615 Protein ID WP_003412752.1
Coordinates 1159052..1159477 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag F6W99_RS05610 Protein ID WP_003412749.1
Coordinates 1158825..1159046 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W99_RS05595 1157065..1157271 - 207 WP_003899347.1 hypothetical protein -
F6W99_RS05600 1157407..1158030 + 624 WP_003900858.1 TIGR00725 family protein -
F6W99_RS05605 1158020..1158772 + 753 WP_064314150.1 hypothetical protein -
F6W99_RS05610 1158825..1159046 + 222 WP_003412749.1 antitoxin Antitoxin
F6W99_RS05615 1159052..1159477 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
F6W99_RS05620 1159500..1160681 - 1182 WP_003899351.1 2-oxo acid dehydrogenase subunit E2 -
F6W99_RS05625 1160678..1161724 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
F6W99_RS05630 1161735..1162838 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
F6W99_RS05635 1163097..1163918 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
F6W99_RS05640 1163915..1164472 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T140744 WP_003412752.1 NZ_CP044345:1159052-1159477 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T140744 NZ_CP059399:955125-955544 [Nocardia sp. WCH-YHL-001]
ATGGGAGTAACCGAGTGGCTCATCGACAAGTCAGCGCTGGTGCGGCTTTCCGGATCGCCGGATATCGATGTCTGGGCGGA
ACGCATCGACCAGGGTCGCGTTCGAGTAGCGACAGTCACCATGCTCGAGGTGGGATTTTCGGCTCGATCTGGACCAGATC
ACCGCGCGGCGTTCTCCCGGCCGCCTCTGTCGTCATTCCTCGTCGAGTACCTGACTCCGACCATGGAGGACCGAGCGCTC
GAGGTTCAGGCCGCACTCGCCGACGCCGGGCATCATCGCGCGCCGTCTGTCGCAGATCTGCTGGTTGCCGCTGTGGCCGA
GTTGTCAGGTCTGACGGTGCTGCATCTGGACAAGGACTTCGAGCTGATCGCCGACGTCACGGGTCAACCTGTGGAGCGAT
TACGGCTCTCGGGTGAATAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT140744 WP_003412749.1 NZ_CP044345:1158825-1159046 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT140744 NZ_CP059399:954910-955134 [Nocardia sp. WCH-YHL-001]
ATGTCGGCAGATCTGTTGATCCGGGACGTACCGGATGATGTCATCGCCGCGATCGATGCCAAGGCCAAACGCCTAGGTCT
ATCGCGGACGCAATATCTTCGCCGCACGCTGGCTCGCGAAGCGGCATCCGATGAACGGCGTGTCACCGCTGCGGATCTCG
TATGGTTCTCGGACACCTTTGCGGATCTCGCAGATGAGGAGGTAATGCGCCGCGCATGGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References