Detailed information of TA system TA140743

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 754471..755000
• Replicon: chromosome
• Accession: NZ_CP044345
• Organism: Mycobacterium tuberculosis strain L

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: F6W99_RS03625
• Protein ID: WP_064314226.1
• Coordinates: 754471..754788 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P9WJ74
• Locus tag: F6W99_RS03630
• Protein ID: WP_003411127.1
• Coordinates: 754785..755000 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F6W99_RS03595	749608..750684	+	1077	WP_003411110.1	hypothetical protein	-
F6W99_RS03600	750681..750962	+	282	WP_003411112.1	hypothetical protein	-
F6W99_RS03605	750998..752071	+	1074	WP_003411116.1	quinone-dependent dihydroorotate dehydrogenase	-
F6W99_RS03610	752076..752606	-	531	WP_003411119.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
F6W99_RS03615	752654..754000	-	1347	WP_003411121.1	M20/M25/M40 family metallo-hydrolase	-
F6W99_RS03625	754471..754788	-	318	WP_064314226.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F6W99_RS03630	754785..755000	-	216	WP_003411127.1	antitoxin ParD2	Antitoxin
F6W99_RS03635	755255..756313	+	1059	WP_003411129.1	hypothetical protein	-
F6W99_RS03640	756443..756799	-	357	WP_003411130.1	hypothetical protein	-
F6W99_RS03645	756894..757676	-	783	WP_003411131.1	cell wall synthesis protein Wag31	-
F6W99_RS03650	757944..758234	-	291	WP_003900476.1	YggT family protein	-
F6W99_RS03655	758396..759052	-	657	WP_003411133.1	cell division protein SepF	-
F6W99_RS03660	759118..759894	-	777	WP_003411137.1	YggS family pyridoxal phosphate-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Conserved hypothetical protein CHP02574, addiction module (11-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12340.93 Da
• Isoelectric Point: 6.4831

>T140743 WP_064314226.1 NZ_CP044345:c754788-754471 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAVPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Nucleotide

• Length: 318 bp

>T140743 NZ_CP059398:c5268905-5268480 [Bradyrhizobium sp. I71]
GTGAACCTGCTCCTCGACACCAATGTGCTGTCGGAGGTTCGTCGGCCGGCGCCTTCCCCGAAAGTCCTGGCGTGGCTCGA
TACAATCGATGAGGACCGCGCGTTCATCAGCGTCGCCTCGATTGCCGAGCTCCGCCGCGGCATCGCTCTGCTGGACGACG
CCCGGCGGCGCACGGCCTTAGCAGCTTGGCTCGTCCATGATCTGCCAGCGCGATTTGCAGGGCGCATCCTGCCGATCGAC
CATGCTGTGGCTGAACGATGGGGCGACCTGATGGCGCAGAGCCGCCGCACTGGTGTTGCACTGTCCGTCATGGACGGCTT
CTTTGCAGCCAGCGCGCTCGTCAGCAACCTCACGCTCGTCACACGCAACGTGAAGGATTTTACGGCCTTCGGCGTCCCGC
TGCACAATCCGTGGGGCGACGCCTAG

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7880.70 Da
• Isoelectric Point: 4.4055

>AT140743 WP_003411127.1 NZ_CP044345:c755000-754785 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Nucleotide

• Length: 216 bp

>AT140743 NZ_CP059398:c5269186-5268902 [Bradyrhizobium sp. I71]
ATGGTCGACCGAAACACTGCACCCGATCCGCTTCCGGCTGATGACATCTGGACACTCGCCAACGCCAAGGCACGGCTGTC
CGAGGTGGTCGACCGCGCTCAAGCTGGCCCTCAGATCATCACCCGGCACGGCAAACCAAATGCAGTGGTCGTTTCCGCTG
AGGAATGGGCACGGAAGACCGCACGCAAAGGCACGCTCGCCGACTTCCTGCTGGCTTCGCCGTTGCGCGGCACTGACCTC
GAGCTTGAACGCATGCGGGATGAACCGCGCAACGAGATGCCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4FAJ4