Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 717734..718429 Replicon chromosome
Accession NZ_CP044345
Organism Mycobacterium tuberculosis strain L

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag F6W99_RS03420 Protein ID WP_003410811.1
Coordinates 717734..718168 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag F6W99_RS03425 Protein ID WP_003410814.1
Coordinates 718175..718429 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W99_RS03410 713888..716929 + 3042 WP_003912728.1 DEAD/DEAH box helicase -
F6W99_RS03415 717039..717755 + 717 WP_003410793.1 SWIM zinc finger family protein -
F6W99_RS03420 717734..718168 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
F6W99_RS03425 718175..718429 - 255 WP_003410814.1 antitoxin Antitoxin
F6W99_RS03430 718445..718702 - 258 WP_003410816.1 hypothetical protein -
F6W99_RS03440 719649..719945 + 297 WP_003410820.1 PE family protein -
F6W99_RS03445 720001..720732 + 732 WP_003900467.1 PPE family protein -
F6W99_RS03450 721272..722018 - 747 WP_003906749.1 proteasome subunit alpha -
F6W99_RS03455 722015..722890 - 876 WP_003411023.1 proteasome subunit beta -
F6W99_RS03460 722887..723081 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T140742 WP_003410811.1 NZ_CP044345:c718168-717734 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T140742 NZ_CP059398:c3661527-3661123 [Bradyrhizobium sp. I71]
ATGGTGATCGACACATCTGCGATCGTGGCCATTGCGTTCAATGAAGCCGATGCAGCCAGTATGGAGCGACTGATCGCGGA
CGATCCAATCCGCCTGATCTCTGCCGCAACCGTGCTCGAAGCAACGATGGTGATCGAAACGCGGCTCGGTGACGCTGGCG
GGCGCGAGCTCGATCTCTGGCTCGTCAAGGTCGGCGCAGAGATCGTGGCAGTAGATGCCTTTCAAGCCGATGCGGCACGG
CGCGCCTGGCGGCGTTACGGGAAGGGGCGTCACACCGCATCGCTCGACTACGGTGATTGCTTTTCTTACGCGCTGGCTAT
GACCCGCAGCGAACCATTGCTGTTCAAAGGCGAGGACTTCGCGAAGACCGATGTCAGCCGACCAGTCGCGGCGCCGCTCC
GATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT140742 WP_003410814.1 NZ_CP044345:c718429-718175 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT140742 NZ_CP059398:c3661781-3661527 [Bradyrhizobium sp. I71]
ATGGCCCTGAGCATCAAGGACCCCGAAACAGAGCAATTGGCGCGAAGCCTGGCGCAATTGACCGGCGAGACCATCACGAC
CGCAACCAAGCGCGCCATCGAGGAGCGATTGCGCAGGCTCGGCAGTCAAACCCGCAAGGACGCCTTGCTGGAGGACATGG
CCGAGATCAGGCGACGCTGGAGCGAAATGCGCGTCGTGGACGACCGTTCGCCCGAGGAAATTCTCGGATATGACGAGCAT
GGATTGCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References