Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
Location | 717734..718429 | Replicon | chromosome |
Accession | NZ_CP044345 | ||
Organism | Mycobacterium tuberculosis strain L |
Toxin (Protein)
Gene name | vapC | Uniprot ID | O53501 |
Locus tag | F6W99_RS03420 | Protein ID | WP_003410811.1 |
Coordinates | 717734..718168 (-) | Length | 145 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TMN0 |
Locus tag | F6W99_RS03425 | Protein ID | WP_003410814.1 |
Coordinates | 718175..718429 (-) | Length | 85 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
F6W99_RS03410 | 713888..716929 | + | 3042 | WP_003912728.1 | DEAD/DEAH box helicase | - |
F6W99_RS03415 | 717039..717755 | + | 717 | WP_003410793.1 | SWIM zinc finger family protein | - |
F6W99_RS03420 | 717734..718168 | - | 435 | WP_003410811.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
F6W99_RS03425 | 718175..718429 | - | 255 | WP_003410814.1 | antitoxin | Antitoxin |
F6W99_RS03430 | 718445..718702 | - | 258 | WP_003410816.1 | hypothetical protein | - |
F6W99_RS03440 | 719649..719945 | + | 297 | WP_003410820.1 | PE family protein | - |
F6W99_RS03445 | 720001..720732 | + | 732 | WP_003900467.1 | PPE family protein | - |
F6W99_RS03450 | 721272..722018 | - | 747 | WP_003906749.1 | proteasome subunit alpha | - |
F6W99_RS03455 | 722015..722890 | - | 876 | WP_003411023.1 | proteasome subunit beta | - |
F6W99_RS03460 | 722887..723081 | - | 195 | WP_003411026.1 | ubiquitin-like protein Pup | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 145 a.a. Molecular weight: 15662.08 Da Isoelectric Point: 7.4681
>T140742 WP_003410811.1 NZ_CP044345:c718168-717734 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL
Download Length: 435 bp
>T140742 NZ_CP059398:c3661527-3661123 [Bradyrhizobium sp. I71]
ATGGTGATCGACACATCTGCGATCGTGGCCATTGCGTTCAATGAAGCCGATGCAGCCAGTATGGAGCGACTGATCGCGGA
CGATCCAATCCGCCTGATCTCTGCCGCAACCGTGCTCGAAGCAACGATGGTGATCGAAACGCGGCTCGGTGACGCTGGCG
GGCGCGAGCTCGATCTCTGGCTCGTCAAGGTCGGCGCAGAGATCGTGGCAGTAGATGCCTTTCAAGCCGATGCGGCACGG
CGCGCCTGGCGGCGTTACGGGAAGGGGCGTCACACCGCATCGCTCGACTACGGTGATTGCTTTTCTTACGCGCTGGCTAT
GACCCGCAGCGAACCATTGCTGTTCAAAGGCGAGGACTTCGCGAAGACCGATGTCAGCCGACCAGTCGCGGCGCCGCTCC
GATAG
ATGGTGATCGACACATCTGCGATCGTGGCCATTGCGTTCAATGAAGCCGATGCAGCCAGTATGGAGCGACTGATCGCGGA
CGATCCAATCCGCCTGATCTCTGCCGCAACCGTGCTCGAAGCAACGATGGTGATCGAAACGCGGCTCGGTGACGCTGGCG
GGCGCGAGCTCGATCTCTGGCTCGTCAAGGTCGGCGCAGAGATCGTGGCAGTAGATGCCTTTCAAGCCGATGCGGCACGG
CGCGCCTGGCGGCGTTACGGGAAGGGGCGTCACACCGCATCGCTCGACTACGGTGATTGCTTTTCTTACGCGCTGGCTAT
GACCCGCAGCGAACCATTGCTGTTCAAAGGCGAGGACTTCGCGAAGACCGATGTCAGCCGACCAGTCGCGGCGCCGCTCC
GATAG
Antitoxin
Download Length: 85 a.a. Molecular weight: 9417.57 Da Isoelectric Point: 8.9912
>AT140742 WP_003410814.1 NZ_CP044345:c718429-718175 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS
Download Length: 255 bp
>AT140742 NZ_CP059398:c3661781-3661527 [Bradyrhizobium sp. I71]
ATGGCCCTGAGCATCAAGGACCCCGAAACAGAGCAATTGGCGCGAAGCCTGGCGCAATTGACCGGCGAGACCATCACGAC
CGCAACCAAGCGCGCCATCGAGGAGCGATTGCGCAGGCTCGGCAGTCAAACCCGCAAGGACGCCTTGCTGGAGGACATGG
CCGAGATCAGGCGACGCTGGAGCGAAATGCGCGTCGTGGACGACCGTTCGCCCGAGGAAATTCTCGGATATGACGAGCAT
GGATTGCCGCGCTGA
ATGGCCCTGAGCATCAAGGACCCCGAAACAGAGCAATTGGCGCGAAGCCTGGCGCAATTGACCGGCGAGACCATCACGAC
CGCAACCAAGCGCGCCATCGAGGAGCGATTGCGCAGGCTCGGCAGTCAAACCCGCAAGGACGCCTTGCTGGAGGACATGG
CCGAGATCAGGCGACGCTGGAGCGAAATGCGCGTCGTGGACGACCGTTCGCCCGAGGAAATTCTCGGATATGACGAGCAT
GGATTGCCGCGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4FB09 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TMN0 |