Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 581540..582126 Replicon chromosome
Accession NZ_CP044345
Organism Mycobacterium tuberculosis strain L

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag F6W99_RS02810 Protein ID WP_003912702.1
Coordinates 581540..581884 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag F6W99_RS02815 Protein ID WP_003410014.1
Coordinates 581878..582126 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W99_RS02770 577246..577845 + 600 WP_003409989.1 L-lysine exporter -
F6W99_RS02775 578261..578689 + 429 WP_003409992.1 cellulose-binding protein -
F6W99_RS02780 578915..579454 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
F6W99_RS02790 579974..580534 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
F6W99_RS02795 580531..580872 - 342 WP_003410003.1 DUF2384 domain-containing protein -
F6W99_RS02800 580958..581215 + 258 WP_003410006.1 hypothetical protein -
F6W99_RS02805 581116..581451 - 336 WP_003410009.1 dehydrogenase -
F6W99_RS02810 581540..581884 - 345 WP_003912702.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
F6W99_RS02815 581878..582126 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
F6W99_RS02820 582226..584541 - 2316 WP_003899120.1 cation transporter ATPase CptG -
F6W99_RS02825 584538..584810 - 273 WP_003410017.1 DUF1490 family protein -
F6W99_RS02830 584863..585219 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
F6W99_RS02835 585376..586143 + 768 WP_003410019.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12260.15 Da        Isoelectric Point: 9.8887

>T140738 WP_003912702.1 NZ_CP044345:c581884-581540 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPSNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

>T140738 NZ_CP059391:c4629346-4629026 [Klebsiella africana]
ATGCAAATCTCAACTGTACCGGCCACGATGCCGGTTTCGTCACGCCTGTCGCCCGTGCAGGTCTGGCAGCAATTGTTAAC
GTATCTGCTGGAGCACCATTACGGCCTGACGCTCAACGACACACCATTCCATGATGATGCGGCCATCAAGGAACATATCG
AGGCGGGTATCACGCTTGCTGATGCGGTGAATTTCCTGGTGGAACGTTATGAACTGGTACGCACTGATCGCAAGGGGTTT
ACGTGGCAGGAGCAGACACCATTTGTAACCGCTACAGATATTCTCAGAGCCAGAAGAGCTACCGGGCTGATGAATAAGTA
A

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT140738 WP_003410014.1 NZ_CP044345:c582126-581878 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp

>AT140738 NZ_CP059391:c4629749-4629414 [Klebsiella africana]
ATGTATAAAGACGCTACACCAACCTGGGGGCTTAGACGAGATATCACTCCGTGTTTCGGAGCCCGACTGGTGCAGGAAGG
TCATCGCCTGCATTTTCTGGCTAACCGGGCAGGATTCACCGGCTCATTCAGTGAGGTGCAGACCTTACAACTGAATGAAG
CCTTCCCGCATTTTGTCGCATATCTGGAGCTGATGCTGCTCTCCTGCGAGCTGAATCCCCGGTACGCGCACTGTGTCACA
CTGTACCGTAACGGGTTGACTTGTGAAGCAGATACGCTGGGCAGTCATGGGCACGTGTATATGGCAATTTATCCCTCAAA
TCAGGTTAAAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7WJ0
PDB 7WNR
AlphaFold DB A0A7U4FAW9

References