Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 579974..580872 Replicon chromosome
Accession NZ_CP044345
Organism Mycobacterium tuberculosis strain L

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag F6W99_RS02790 Protein ID WP_003410001.1
Coordinates 579974..580534 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag F6W99_RS02795 Protein ID WP_003410003.1
Coordinates 580531..580872 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W99_RS02755 575143..575796 - 654 WP_003409976.1 cutinase Cfp21 -
F6W99_RS02760 575911..576141 + 231 WP_003409980.1 DUF167 domain-containing protein -
F6W99_RS02765 576226..577137 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
F6W99_RS02770 577246..577845 + 600 WP_003409989.1 L-lysine exporter -
F6W99_RS02775 578261..578689 + 429 WP_003409992.1 cellulose-binding protein -
F6W99_RS02780 578915..579454 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
F6W99_RS02790 579974..580534 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
F6W99_RS02795 580531..580872 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
F6W99_RS02800 580958..581215 + 258 WP_003410006.1 hypothetical protein -
F6W99_RS02805 581116..581451 - 336 WP_003410009.1 dehydrogenase -
F6W99_RS02810 581540..581884 - 345 WP_003912702.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
F6W99_RS02815 581878..582126 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
F6W99_RS02820 582226..584541 - 2316 WP_003899120.1 cation transporter ATPase CptG -
F6W99_RS02825 584538..584810 - 273 WP_003410017.1 DUF1490 family protein -
F6W99_RS02830 584863..585219 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T140737 WP_003410001.1 NZ_CP044345:c580534-579974 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T140737 NZ_CP059391:3989271-3989489 [Klebsiella africana]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGCCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCAGCCGATCATCGCCTGGCTGAAC
TGACTATGAATAAGCTCTACGATAAGATCCCGACCTCGGTCTGGAAGTTTATCCGCTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT140737 WP_003410003.1 NZ_CP044345:c580872-580531 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT140737 NZ_CP059391:3988870-3989244 [Klebsiella africana]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGGTGGGTTAACGACCCGACATCGGCTGTCAATCTTCAGTTAAATGAATTGATCGAGC
ACATTGCCACGTTCGCGCTTAATTATAAAATTAAGTATGCGGAGGATAATAAACTGATCGATCAAGTTGACGAATATCTG
GACGATACTTTCACATTGTTCAGTAACTACGGCATTAACTCCTCGGATTTGCAGAAGTGGAAAAAATCCGGTAATCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAATCCGGCTAGTCTTTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References