Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 572646..573334 Replicon chromosome
Accession NZ_CP044345
Organism Mycobacterium tuberculosis strain L

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag F6W99_RS02740 Protein ID WP_003409958.1
Coordinates 572646..573065 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag F6W99_RS02745 Protein ID WP_003409968.1
Coordinates 573074..573334 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W99_RS02720 568141..568989 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
F6W99_RS02725 568952..570397 - 1446 WP_003899115.1 APC family permease -
F6W99_RS02730 570576..571262 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
F6W99_RS02735 571453..572421 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
F6W99_RS02740 572646..573065 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
F6W99_RS02745 573074..573334 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
F6W99_RS02750 573477..575155 + 1679 Protein_528 PecA family PE domain-processing aspartic protease -
F6W99_RS02755 575143..575796 - 654 WP_003409976.1 cutinase Cfp21 -
F6W99_RS02760 575911..576141 + 231 WP_003409980.1 DUF167 domain-containing protein -
F6W99_RS02765 576226..577137 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
F6W99_RS02770 577246..577845 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T140736 WP_003409958.1 NZ_CP044345:c573065-572646 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T140736 NZ_CP059391:c2656256-2654934 [Klebsiella africana]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCGCTCTCGCTGCCGCTGCAGTATGGCAATATCACTG
CCGATGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCAAAGCAGCCGTTCGATCTACTGGCCGAAGTTGGGCGCGATAGCGTAGGGGCGGTAACCCTCCTGCCGCCGGG
GGAAGAGGCGCATCTGGAGGCGTTGCGCTGGCAGACGCTGGACGAGACGCAGCTCACCTCTCTGCTGACCGCCTACCAGT
CGGATATTCCCCTCGGGATGATTACCGACCAGGATGATTTCCGTATCTCGGTGGCTGGCGCCCAGGAGAAAACGGCGCTG
CTGCGAATGGGCGATCACTGGTGTATTCCGCAGGGCACCACGCCGACCACGCATATCATTAAGCTGCCGATCGGCGAGAT
AAAGCAGCCGAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAGTATCTGTGCCTGACGCTGGCCAGAGAACTTG
GCCTGGCGGTGCCGGAGGCGGAGATCATCACCACCCCGCGGATCCGCGCGCTGGCGGTGACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGGCGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCCTTTGGTCTTCCTTCAGCGATGAAATA
TGAATCTGACGGCGGGCCGGGGATCGCCGCGATGATGTCTTTTCTGCTGGGCTCCAGTGAAGCCCTGAAAGACCGCAATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGGAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTATGGCGACCGCCAAAGCGGTGAATTTTCCTCGGGAGCAGATGCTGGCCATCCTCCAGGAGTTTGCTGAGCGCGTGCCG
CAGACTATTGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCACCCACGTCTGGCAGGCCATTACAGAGAATGTGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGTTATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT140736 WP_003409968.1 NZ_CP044345:c573334-573074 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT140736 NZ_CP059391:c2656522-2656256 [Klebsiella africana]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAGCTACCTGAAGCTGCTGCGCCAGCAGAATCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCCACAGAGACGGCCCCGGCTCCT
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References