Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 572646..573334 | Replicon | chromosome |
Accession | NZ_CP044345 | ||
Organism | Mycobacterium tuberculosis strain L |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P0A653 |
Locus tag | F6W99_RS02740 | Protein ID | WP_003409958.1 |
Coordinates | 572646..573065 (-) | Length | 140 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P9WJ28 |
Locus tag | F6W99_RS02745 | Protein ID | WP_003409968.1 |
Coordinates | 573074..573334 (-) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
F6W99_RS02720 | 568141..568989 | + | 849 | WP_003409942.1 | class I SAM-dependent methyltransferase | - |
F6W99_RS02725 | 568952..570397 | - | 1446 | WP_003899115.1 | APC family permease | - |
F6W99_RS02730 | 570576..571262 | - | 687 | WP_003409954.1 | immunoprotective protein Mpt64 | - |
F6W99_RS02735 | 571453..572421 | - | 969 | WP_003899116.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
F6W99_RS02740 | 572646..573065 | - | 420 | WP_003409958.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
F6W99_RS02745 | 573074..573334 | - | 261 | WP_003409968.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
F6W99_RS02750 | 573477..575155 | + | 1679 | Protein_528 | PecA family PE domain-processing aspartic protease | - |
F6W99_RS02755 | 575143..575796 | - | 654 | WP_003409976.1 | cutinase Cfp21 | - |
F6W99_RS02760 | 575911..576141 | + | 231 | WP_003409980.1 | DUF167 domain-containing protein | - |
F6W99_RS02765 | 576226..577137 | - | 912 | WP_003409986.1 | ArgP/LysG family DNA-binding transcriptional regulator | - |
F6W99_RS02770 | 577246..577845 | + | 600 | WP_003409989.1 | L-lysine exporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 14724.89 Da Isoelectric Point: 7.9535
>T140736 WP_003409958.1 NZ_CP044345:c573065-572646 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA
Download Length: 420 bp
>T140736 NZ_CP059391:c2656256-2654934 [Klebsiella africana]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCGCTCTCGCTGCCGCTGCAGTATGGCAATATCACTG
CCGATGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCAAAGCAGCCGTTCGATCTACTGGCCGAAGTTGGGCGCGATAGCGTAGGGGCGGTAACCCTCCTGCCGCCGGG
GGAAGAGGCGCATCTGGAGGCGTTGCGCTGGCAGACGCTGGACGAGACGCAGCTCACCTCTCTGCTGACCGCCTACCAGT
CGGATATTCCCCTCGGGATGATTACCGACCAGGATGATTTCCGTATCTCGGTGGCTGGCGCCCAGGAGAAAACGGCGCTG
CTGCGAATGGGCGATCACTGGTGTATTCCGCAGGGCACCACGCCGACCACGCATATCATTAAGCTGCCGATCGGCGAGAT
AAAGCAGCCGAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAGTATCTGTGCCTGACGCTGGCCAGAGAACTTG
GCCTGGCGGTGCCGGAGGCGGAGATCATCACCACCCCGCGGATCCGCGCGCTGGCGGTGACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGGCGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCCTTTGGTCTTCCTTCAGCGATGAAATA
TGAATCTGACGGCGGGCCGGGGATCGCCGCGATGATGTCTTTTCTGCTGGGCTCCAGTGAAGCCCTGAAAGACCGCAATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGGAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTATGGCGACCGCCAAAGCGGTGAATTTTCCTCGGGAGCAGATGCTGGCCATCCTCCAGGAGTTTGCTGAGCGCGTGCCG
CAGACTATTGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCACCCACGTCTGGCAGGCCATTACAGAGAATGTGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGTTATAG
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCGCTCTCGCTGCCGCTGCAGTATGGCAATATCACTG
CCGATGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCAAAGCAGCCGTTCGATCTACTGGCCGAAGTTGGGCGCGATAGCGTAGGGGCGGTAACCCTCCTGCCGCCGGG
GGAAGAGGCGCATCTGGAGGCGTTGCGCTGGCAGACGCTGGACGAGACGCAGCTCACCTCTCTGCTGACCGCCTACCAGT
CGGATATTCCCCTCGGGATGATTACCGACCAGGATGATTTCCGTATCTCGGTGGCTGGCGCCCAGGAGAAAACGGCGCTG
CTGCGAATGGGCGATCACTGGTGTATTCCGCAGGGCACCACGCCGACCACGCATATCATTAAGCTGCCGATCGGCGAGAT
AAAGCAGCCGAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAGTATCTGTGCCTGACGCTGGCCAGAGAACTTG
GCCTGGCGGTGCCGGAGGCGGAGATCATCACCACCCCGCGGATCCGCGCGCTGGCGGTGACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGGCGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCCTTTGGTCTTCCTTCAGCGATGAAATA
TGAATCTGACGGCGGGCCGGGGATCGCCGCGATGATGTCTTTTCTGCTGGGCTCCAGTGAAGCCCTGAAAGACCGCAATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGGAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTATGGCGACCGCCAAAGCGGTGAATTTTCCTCGGGAGCAGATGCTGGCCATCCTCCAGGAGTTTGCTGAGCGCGTGCCG
CAGACTATTGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCACCCACGTCTGGCAGGCCATTACAGAGAATGTGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGTTATAG
Antitoxin
Download Length: 87 a.a. Molecular weight: 9528.88 Da Isoelectric Point: 5.1007
>AT140736 WP_003409968.1 NZ_CP044345:c573334-573074 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV
Download Length: 261 bp
>AT140736 NZ_CP059391:c2656522-2656256 [Klebsiella africana]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAGCTACCTGAAGCTGCTGCGCCAGCAGAATCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCCACAGAGACGGCCCCGGCTCCT
GATAACAACACGGACCTTGACTGGTAA
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAGCTACCTGAAGCTGCTGCGCCAGCAGAATCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCCACAGAGACGGCCCCGGCTCCT
GATAACAACACGGACCTTGACTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829C4H9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829C483 |