Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 550911..551455 Replicon chromosome
Accession NZ_CP044345
Organism Mycobacterium tuberculosis strain L

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag F6W99_RS02610 Protein ID WP_003409896.1
Coordinates 550911..551207 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag F6W99_RS02615 Protein ID WP_003409899.1
Coordinates 551204..551455 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W99_RS02555 545942..546292 - 351 WP_003899096.1 hypothetical protein -
F6W99_RS02560 546303..547205 - 903 WP_003899097.1 hypothetical protein -
F6W99_RS02565 547226..547417 - 192 WP_003409876.1 hypothetical protein -
F6W99_RS02570 547418..547714 - 297 WP_003409877.1 hypothetical protein -
F6W99_RS02575 547954..548169 + 216 WP_003409878.1 antitoxin -
F6W99_RS02580 548166..548477 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
F6W99_RS21590 548451..548972 - 522 WP_003904745.1 hypothetical protein -
F6W99_RS02590 548947..549324 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
F6W99_RS02595 549366..549815 + 450 WP_003913306.1 type II toxin-antitoxin system antitoxin HigA -
F6W99_RS02600 549812..550357 + 546 WP_003409891.1 SecB-like chaperone -
F6W99_RS02605 550246..550861 - 616 Protein_501 hypothetical protein -
F6W99_RS02610 550911..551207 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F6W99_RS02615 551204..551455 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
F6W99_RS02620 551442..551936 + 495 WP_003899099.1 hypothetical protein -
F6W99_RS02625 552096..552503 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
F6W99_RS02630 552507..552779 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
F6W99_RS02635 552812..554032 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
F6W99_RS02650 554931..555728 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T140735 WP_003409896.1 NZ_CP044345:c551207-550911 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T140735 NZ_CP059391:1963716-1963818 [Klebsiella africana]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT140735 WP_003409899.1 NZ_CP044345:c551455-551204 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT140735 NZ_CP059391:c1963820-1963680 [Klebsiella africana]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References