Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 324975..325435 Replicon chromosome
Accession NZ_CP044345
Organism Mycobacterium tuberculosis strain L

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag F6W99_RS01490 Protein ID WP_003898996.1
Coordinates 325187..325435 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag F6W99_RS01485 Protein ID WP_003408528.1
Coordinates 324975..325187 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W99_RS01470 321454..322641 - 1188 WP_003898992.1 nitrate transporter NarK -
F6W99_RS01475 322928..323212 + 285 WP_003408522.1 DUF1876 domain-containing protein -
F6W99_RS01480 323226..324907 - 1682 Protein_286 SulP family inorganic anion transporter -
F6W99_RS01485 324975..325187 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
F6W99_RS01490 325187..325435 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
F6W99_RS01495 325443..326180 + 738 WP_003898997.1 hypothetical protein -
F6W99_RS01500 326274..327974 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
F6W99_RS01505 328259..328660 - 402 WP_003408538.1 hypothetical protein -
F6W99_RS01510 328650..329261 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T140732 WP_003898996.1 NZ_CP044345:325187-325435 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T140732 NZ_CP059391:740886-741371 [Klebsiella africana]
ATGATCTCTGCCCCTGAGCCGCTTCACGCCGGGCATATTCTTACTCCATTCTGCAGTGGCGTGGATTCGATGGATAACTG
GCTGAAACAGCGGGCGATGAAGAACCAGCTTTCTGGCGCATCCCGCACGTTTGTCTGCTGCGACGATGCGAAGGTAATGG
CGTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCTGGTCGTTTTCGCCGCAATATGCCTGATCCGATC
CCGGTTGTGGTGCTGGGTCGTCTGGCGGTGGAGAAATCACTACATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGCTGATGGTGACGTTGGGGGATTTGGTTCAT
GCTTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT140732 WP_003408528.1 NZ_CP044345:324975-325187 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT140732 NZ_CP059391:740596-740889 [Klebsiella africana]
ATGCCAGCCGCAAACAGTATGACGATGAAACGCGAAACCTTGAACCTGCGCATCAAGCCCGCCGAGCGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGTTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGAGCCCAAT
GCCGCATTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAACAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References