140730

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 129902..130530 Replicon chromosome
Accession NZ_CP044345
Organism Mycobacterium tuberculosis strain L

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag F6W99_RS00605 Protein ID WP_003407786.1
Coordinates 130126..130530 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WLU3
Locus tag F6W99_RS00600 Protein ID WP_003407785.1
Coordinates 129902..130120 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W99_RS00570 125322..125702 + 381 WP_003407768.1 fumarate reductase subunit C -
F6W99_RS00575 125699..126076 + 378 WP_003407771.1 fumarate reductase subunit FrdD -
F6W99_RS00580 126144..126752 + 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
F6W99_RS00585 126891..128084 + 1194 WP_003901197.1 MMPL family transporter -
F6W99_RS00590 128094..128540 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
F6W99_RS00595 128575..129864 + 1290 WP_003407781.1 threonine ammonia-lyase -
F6W99_RS00600 129902..130120 + 219 WP_003407785.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
F6W99_RS00605 130126..130530 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
F6W99_RS00610 130547..132289 - 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
F6W99_RS00615 132282..134579 - 2298 WP_003407790.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(7-49)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T140730 WP_003407786.1 NZ_CP044345:130126-130530 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

>T140730 NZ_CP059390:c4453-4112 [Acinetobacter baumannii]
ATGCCTCAAAATTATGTACCAGAAGAAGGCGATATTATCTGGATTAATTTTAATCCACAGAGTGGGCATGAACAGGCAGG
ACATAGACCTGCCTTAGTTTTAAGTCCTTCATCTTATAATAAAGCCACAAGCCTACTAGTTTGCTGTCCAATGACAACGC
AGATAAAAGGGTATCCTTTCGAAGTTAAAATTGTAGGAAATCCTGAAAATGTAGCACTATCTGATCAAGTAAAAAGTTTA
GATTGGGTCGCTCGATCAGCAACGAAAAAGGGACAAGCTAAATCTGAAGAACTTGAGGAAGTGCGACAAAAAATTGCAGC
CTTACTGAAAATATCAACTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8209.32 Da        Isoelectric Point: 4.5600

>AT140730 WP_003407785.1 NZ_CP044345:129902-130120 [Mycobacterium tuberculosis]
VYRWCMSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 219 bp

>AT140730 NZ_CP059390:c4692-4453 [Acinetobacter baumannii]
ATGGAACTAGCTATTAAAAAGTGGGGCAATAGTGCTGCTGTCCGCCTACCATCCATTTTATTAGAAAGCCTTAATCTTAA
ATTGGATAGCCGTGTTGAGGTATTTACTCAAGATGAAGCGATCGTTATCAAGCCAATTAAATCAAAAATATCTTTAGAGC
AGCTTTTAGCAGATATAACATCTGATAATTTGCATTGTGAAGTGGATACTGGACATGCTGTAGGTAAGGAAATCTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB P9WLU3

References