Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2935173..2935829 Replicon chromosome
Accession NZ_CP044335
Organism Enterobacter hormaechei strain AKB48

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D6T76_RS13750 Protein ID WP_006812483.1
Coordinates 2935437..2935829 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D6T76_RS13745 Protein ID WP_058677107.1
Coordinates 2935173..2935433 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D6T76_RS13720 2930391..2931512 - 1122 WP_169723568.1 efflux RND transporter periplasmic adaptor subunit -
D6T76_RS13725 2931660..2932229 - 570 WP_169723569.1 TetR/AcrR family transcriptional regulator -
D6T76_RS13730 2932415..2932825 + 411 Protein_2685 GNAT family N-acetyltransferase -
D6T76_RS13735 2932830..2933477 - 648 WP_169723570.1 TetR/AcrR family transcriptional regulator -
D6T76_RS13740 2933556..2935055 + 1500 WP_169723571.1 MFS transporter -
D6T76_RS13745 2935173..2935433 + 261 WP_058677107.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
D6T76_RS13750 2935437..2935829 + 393 WP_006812483.1 type II toxin-antitoxin system VapC family toxin Toxin
D6T76_RS13755 2935898..2936371 - 474 WP_169723572.1 hypothetical protein -
D6T76_RS13760 2936753..2937553 + 801 WP_023302839.1 lipoprotein NlpA -
D6T76_RS13765 2937587..2938267 - 681 WP_169723573.1 EAL domain-containing protein -
D6T76_RS13770 2938343..2938963 - 621 WP_169723574.1 response regulator transcription factor -
D6T76_RS13775 2939534..2940169 + 636 WP_169724776.1 DNA-binding response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14587.75 Da        Isoelectric Point: 5.8985

>T140721 WP_006812483.1 NZ_CP044335:2935437-2935829 [Enterobacter hormaechei]
MLHMLDTNIVSHLVRQHPEVVNRYSQITPEKMCISSVTEAELLYGVAKKQNNKLHETIMEFLKTITICAWDSEAAATYGE
LRAAMEKKGKVMGDLDQLIAAHAISRGTTIVTNDHAFGMVQDLTVEDWTQ

Download         Length: 393 bp

>T140721 NZ_CP059386:c865801-865412 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTACTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10142.42 Da        Isoelectric Point: 8.5751

>AT140721 WP_058677107.1 NZ_CP044335:2935173-2935433 [Enterobacter hormaechei]
MERTAKLFKKGRNQAVVLPAEFAFETESVYIRRDDEGNVVLTARSEKERHRDNFLRMLKETHVPDTFLSKEERNQSYTTR
NPLEGL

Download         Length: 261 bp

>AT140721 NZ_CP059386:c866053-865808 [Acinetobacter baumannii]
ATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTTTGACCCTTATGT
GAAAAATTATTATTTAAAGGCAGAGCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAGACCCTGATTTAC
TCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAACACTATGTTCAT
GGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References