Detailed information of TA system TA140706

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 717918..718657
• Replicon: chromosome
• Accession: NZ_CP044335
• Organism: Enterobacter hormaechei strain AKB48

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: D6T76_RS03405
• Protein ID: WP_169722113.1
• Coordinates: 717918..718403 (-)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: A0A837FCR9
• Locus tag: D6T76_RS03410
• Protein ID: WP_003857131.1
• Coordinates: 718391..718657 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D6T76_RS03375	713014..713982	-	969	WP_169722060.1	IS5 family transposase	-
D6T76_RS03380	714014..714384	-	371	Protein_668	transposase	-
D6T76_RS03385	714459..714857	+	399	Protein_669	hypothetical protein	-
D6T76_RS03390	714930..715910	+	981	WP_149410115.1	IS5-like element ISKpn26 family transposase	-
D6T76_RS03395	716067..716291	+	225	Protein_671	hypothetical protein	-
D6T76_RS03400	716320..717723	-	1404	WP_169722112.1	ISNCY-like element ISKpn21 family transposase	-
D6T76_RS03405	717918..718403	-	486	WP_169722113.1	GNAT family N-acetyltransferase	Toxin
D6T76_RS03410	718391..718657	-	267	WP_003857131.1	DUF1778 domain-containing protein	Antitoxin
D6T76_RS03415	718721..719650	-	930	WP_169722114.1	LysR family transcriptional regulator	-
D6T76_RS03420	719780..721161	+	1382	Protein_676	MFS transporter	-
D6T76_RS03425	721183..722178	-	996	WP_169722115.1	DUF2891 domain-containing protein	-
D6T76_RS03430	722188..723174	-	987	WP_017382341.1	DUF979 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (54-151)

Antitoxin

• Vibrio phage ICP1, Orf50 (6-82)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17614.38 Da
• Isoelectric Point: 10.2240

>T140706 WP_169722113.1 NZ_CP044335:c718403-717918 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNRALGAARMFVVCKTGTKQVAGFYSLSTGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Nucleotide

• Length: 486 bp

>T140706 NZ_CP059351:448635-449024 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10090.50 Da
• Isoelectric Point: 4.3837

>AT140706 WP_003857131.1 NZ_CP044335:c718657-718391 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Nucleotide

• Length: 267 bp

>AT140706 NZ_CP059351:448371-448628 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A837FCR9