Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 446068..446594 Replicon chromosome
Accession NZ_CP044335
Organism Enterobacter hormaechei strain AKB48

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D6T76_RS02185 Protein ID WP_156652399.1
Coordinates 446307..446594 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag D6T76_RS02180 Protein ID WP_000534858.1
Coordinates 446068..446307 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D6T76_RS02165 442393..443631 + 1239 Protein_426 IS110 family transposase -
D6T76_RS02170 444106..444678 + 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
D6T76_RS02175 444883..445806 + 924 WP_169721942.1 cation diffusion facilitator family transporter -
D6T76_RS02180 446068..446307 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
D6T76_RS02185 446307..446594 + 288 WP_156652399.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
D6T76_RS02190 446696..446821 - 126 WP_151884424.1 division septum protein Blr -
D6T76_RS02195 447061..448101 + 1041 WP_169721943.1 oxidoreductase -
D6T76_RS02200 448158..449156 - 999 WP_015570661.1 adenosine deaminase -
D6T76_RS02205 449253..450425 - 1173 WP_169721944.1 pyridoxal phosphate-dependent aminotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11253.27 Da        Isoelectric Point: 10.3315

>T140705 WP_156652399.1 NZ_CP044335:446307-446594 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYRVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T140705 NZ_CP059350:448638-449027 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT140705 WP_000534858.1 NZ_CP044335:446068-446307 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT140705 NZ_CP059350:448374-448631 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References