Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 3031112..3031626 Replicon chromosome
Accession NZ_CP044328
Organism Methylocystis rosea strain BRCS1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag F7D13_RS14550 Protein ID WP_154453440.1
Coordinates 3031300..3031626 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag F7D13_RS14545 Protein ID WP_026223051.1
Coordinates 3031112..3031300 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7D13_RS14525 3026309..3027238 + 930 WP_154453436.1 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase -
F7D13_RS18340 3027264..3027494 - 231 WP_195838293.1 hypothetical protein -
F7D13_RS14530 3027409..3028308 + 900 WP_154453437.1 outer membrane protein assembly factor BamD -
F7D13_RS14535 3028252..3029187 - 936 WP_154453438.1 alpha/beta hydrolase -
F7D13_RS14540 3029300..3030979 + 1680 WP_154453439.1 DNA repair protein RecN -
F7D13_RS14545 3031112..3031300 + 189 WP_026223051.1 antitoxin MazE family protein Antitoxin
F7D13_RS14550 3031300..3031626 + 327 WP_154453440.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
F7D13_RS14555 3031679..3032551 + 873 WP_154453441.1 chorismate mutase -
F7D13_RS14560 3032557..3032982 - 426 WP_154453442.1 type II toxin-antitoxin system VapC family toxin -
F7D13_RS14565 3032979..3033488 - 510 WP_109025531.1 hypothetical protein -
F7D13_RS14570 3033633..3034763 + 1131 WP_154453443.1 histidinol-phosphate transaminase -
F7D13_RS14575 3034756..3035679 + 924 WP_154453444.1 prephenate/arogenate dehydrogenase family protein -
F7D13_RS14580 3035721..3036416 + 696 WP_154453445.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-104)

Antitoxin

Antitoxin MazE-like

(2-59)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11560.42 Da        Isoelectric Point: 5.0633

>T140695 WP_154453440.1 NZ_CP044328:3031300-3031626 [Methylocystis rosea]
MRRGAFVVVATSGDYGKPRPALVVQSDLFAELPSVVICPLTTTLRDDADLFRLDVEPSARNGLRQASQIAVDKLTVVPSS
KIGEVIGEADDALLLRVNRALALFLGIV

Download         Length: 327 bp

>T140695 NZ_CP059347:4332709-4333674 [Providencia rettgeri]
ATGAAACTCGATAGCTCTTTATTTATTGATGTTGCCGATGCCATAGGGCTCGGCAACCCAGCGATAGTTGAAAAAGATTA
TTATGTTGTTCAATTACTTAAACTCCTATCTAACTTTCAGTTTACATATCACCAAGCTATCTTTTCAGGAGGAACAGCTC
TCGCCAAATCGGATATCAAAACTTATCGAATGTCTGAAGACATTGATATAAAACTAATTCCAAACCAAAGATATTCTGAA
TTAGCATCTCGAAATGCAAGAAAAACAGCCCGAAGAGAAATAAAAAACATTATTGAAGAAATAATTAACCAAAATTCTAT
TTTTTCTTTAGATAATGCGCCTTCTGTTAAAGATGAATACCGCTATTTTTCCTTTGATATCCGTTATCCTCAAGATCACA
GGCAAGCACCATGTTTACGTCCTTTTATAAAATTAGAATTTATAGAGACAGACCTTCTTAGTGAACCCATATCTAGGAAT
ATTCAATCTATTTATTCAAATGTTACAGAATCTGATATCGAAATTTATAACATGATTTGCTCGGCAATTATTGACACTCA
AGCTGAAAAGTTACTATCGATGCTACGAAGAACAGCGAGTGTCGCAAGAAATGGCCAACGTGAAGATGATGAGACACTTA
TTCGACATGTTTATGATACTTTTCATATACAGCTATCCCAACCATCTAATATTGAATTCTTAAGTCAATTACTGAAAAAA
GCACTTGATGGAGATATTACAAGATATGGAAATCAACATACACAACTGGTTGACTCGCCTATTACAGAACTTCGCTATGG
GCTAAAATTATTAGTAGAAACCCCAAAATTCATAGAGCGTTATAATAACTATGTAAGTCCTATGGTTTATGCAGAAGTTC
CTACTCAATGGGATGAAGCAATTATTGCTTTTACTAGCTTAGCTCATCAAGTATTGGATTATATAGAACAAGAACTTAAT
AAATAA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 7174.16 Da        Isoelectric Point: 6.4497

>AT140695 WP_026223051.1 NZ_CP044328:3031112-3031300 [Methylocystis rosea]
MASYRQRMRAAGLRPVQIWAPDSRAPDFIEKCHRQARAVAIHDPAGDEIMQFVASMYEWPED

Download         Length: 189 bp

>AT140695 NZ_CP059347:4332318-4332722 [Providencia rettgeri]
ATGACAATACAAGACAGAATACAAAAAAAAGTAAAGCGTTCTAAACGTTCTGTTTTCCTACGCTCTGACTTTTCAAAAAT
AGCTGATTATGATCAAGTAGGCCGTATACTCAAAAAACTTACAGACAATGGTTTATTAATGAGAATTGGTTATGGTGTCT
ATGTAAGAGCCAGAGTGAATCGCATCACTGGTAAATTAATGCCAGATAACCCAAGTGGTGCTGATGGCGTTATTATCGAA
GTAATGAAAAAACTCAATGTTGATTATACTTTTGATAAGCTATCTCTGATGAATTTGTCTGGTGAGAGTACACAAATTCC
TTCTAATATTAAAATCATCCCTAAAAATCCTAAATTTACTCGTAAAATTAAGGTAGGGAAACAAAGTATCAATGAAACTC
GATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References