Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2235368..2236014 Replicon chromosome
Accession NZ_CP044328
Organism Methylocystis rosea strain BRCS1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag F7D13_RS10800 Protein ID WP_154452581.1
Coordinates 2235368..2235769 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag F7D13_RS10805 Protein ID WP_154452583.1
Coordinates 2235772..2236014 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7D13_RS10780 2230500..2232365 + 1866 WP_154452571.1 extracellular solute-binding protein -
F7D13_RS10785 2232470..2232844 + 375 WP_154452575.1 DUF971 domain-containing protein -
F7D13_RS10790 2232919..2233548 - 630 WP_154452577.1 L,D-transpeptidase -
F7D13_RS10795 2233730..2235316 - 1587 WP_154452579.1 phosphoglycerate dehydrogenase -
F7D13_RS10800 2235368..2235769 - 402 WP_154452581.1 type II toxin-antitoxin system VapC family toxin Toxin
F7D13_RS10805 2235772..2236014 - 243 WP_154452583.1 antitoxin Antitoxin
F7D13_RS10810 2236070..2237251 - 1182 WP_154452585.1 phosphoserine transaminase -
F7D13_RS10815 2237431..2237748 + 318 WP_154452587.1 hypothetical protein -
F7D13_RS10820 2237754..2238050 - 297 WP_109024739.1 BolA family transcriptional regulator -
F7D13_RS10825 2238137..2238736 + 600 WP_154452589.1 J domain-containing protein -
F7D13_RS10830 2238878..2239828 + 951 WP_192879556.1 cobaltochelatase subunit CobS -
F7D13_RS10835 2240038..2240265 + 228 WP_018406116.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14560.00 Da        Isoelectric Point: 8.7319

>T140694 WP_154452581.1 NZ_CP044328:c2235769-2235368 [Methylocystis rosea]
VRFLLDTNAVIAILKGENSSLALRLRQHRPADICLSSIVTHELYFGAYKSGRVEANLACLRALRFEVLPFDLEDSIVAGE
IRAKLRAKGVPIGPYDLLIAAQALGRGLVLVTANVKEFCRVDGLKIQDWTNAG

Download         Length: 402 bp

>T140694 NZ_CP059347:c3988485-3988072 [Providencia rettgeri]
ATGAGTACTACATGGAGAGTAGTTGTGGCGTTCTATAAAATTTCATCATTTAAGCGAAGCACTAAAAAAATCAATATAAA
AGATAAACAGTTACTTAAGGCTGCAAATGAAGTTTTACAGGGGTTTTATGAGGCAGACTTAGGGAGCGGTGTAATTAAAA
AAAGGATCGCGATTAATGGGAAAGGGAAAAGTGGTGGGATCAGAGTTATTATCTTCTTTAAAGCAAGCCACCATCTCTTT
TTTGCTGATGGGTGGGATAAAAGTAATATAAGTTCCAAAGGAGCAAAGGAAATTGCAGAAGATGAGTTAGATGCATATAA
GGGCCTATCTCGACTTTTTCTTAGCTATACGGATGATAAAATTGCTGATTTAGTTTTGTGTAATATTTTGGAGGAACTTA
CTGATGAGCAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9375.71 Da        Isoelectric Point: 4.6583

>AT140694 WP_154452583.1 NZ_CP044328:c2236014-2235772 [Methylocystis rosea]
VDKAKVFWSGRSQAVRLPKDYRIEADEVRISRRGDSIILEPIPKDWSWLDAIVGTMSEDFMEEGREQPPMQERPLLDKLF

Download         Length: 243 bp

>AT140694 NZ_CP059347:c3988082-3987753 [Providencia rettgeri]
ATGAGCAATAAATTAGAAAACATGCTTGAGCTAGCTAAAGAATTACATAATGTTGATGCGGCACCAGAAAGTTTAGTTAA
TGATTTAGAAAGGAAAGTTAGAGCTCGAAATATAAATAAAAAAATAAAAGTTATACCTATGATGAGTGGTGCACAAATAA
AGCAACTCCGTGCTCAATATGGAATGTCGCAAGCAACATTAGCTTTAGTTTTAGGTATGTCTAAGGAAAGCGTTTCTAAG
TGGGAAAGAGAAGAAAAAAAACCCAGCGGCCCAGCTCTTCGCATGTTACATCTTATAGAGCAACGAGGGCCTGAGATTTT
AATTATTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References