Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 462413..463128 Replicon chromosome
Accession NZ_CP044328
Organism Methylocystis rosea strain BRCS1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag F7D13_RS02235 Protein ID WP_154450855.1
Coordinates 462706..463128 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag F7D13_RS02230 Protein ID WP_154450854.1
Coordinates 462413..462709 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7D13_RS02220 458553..461132 - 2580 WP_154450852.1 ATP-dependent helicase HrpB -
F7D13_RS02225 461282..462271 - 990 WP_154450853.1 TIM44-like domain-containing protein -
F7D13_RS02230 462413..462709 + 297 WP_154450854.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F7D13_RS02235 462706..463128 + 423 WP_154450855.1 type II toxin-antitoxin system VapC family toxin Toxin
F7D13_RS02240 463217..464020 + 804 WP_154450856.1 thymidylate synthase -
F7D13_RS02245 464027..464542 + 516 WP_154450857.1 dihydrofolate reductase -
F7D13_RS02255 465058..465933 + 876 WP_154450858.1 lipase family protein -
F7D13_RS02260 466081..466830 - 750 WP_154450859.1 porin family protein -
F7D13_RS02265 467119..467787 - 669 WP_154450860.1 M15 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(20-69)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15963.53 Da        Isoelectric Point: 9.7262

>T140692 WP_154450855.1 NZ_CP044328:462706-463128 [Methylocystis rosea]
VSGWLLDTNVLSELRRPRPNAKVVAFVAAQPLDRLYVSVVTFAEIRFGIELIADPSRRAELHDWLTLKVRPLFTQRTLPV
SEDVMLKWRLLVEEGRKTRYTFSQPDLIIAATALLHGLTVVTRDTGDFEKARAPVVNPWE

Download         Length: 423 bp

>T140692 NZ_CP059347:c3823159-3822647 [Providencia rettgeri]
ATGACATTGAAGCTAACAGCGCCAGAACCACTAAAAACAGGCCATTTACTGGAAGGGTTTTCCTCTGGTGAAGAGGCATT
GGATCTCTGGTTAAAAAACCGGGCAATGAGTTATCAAAACTCAGGGGCCTCGCGCACTTTTGTGACCACTTCGGATAACC
AAGTAATGGGTTACTATGCCTTGTCCACCGGGGTTGTGAGCACCAATCAAGCCGCTGGGCGATTTCGCCGCAACATGCCC
TCTGACATTCCCGTCATCTTACTCGGCAGGCTAGCTGTAGATACAAGGGCGAAGGGTCTTGGAGTTGGTAGGGGGTTAGT
TAAAGATGCCTGTCATCGTGTTATTCAGGCTTCTGGGCTGGTGGGCATTCGAGGGGTTGTGGTTCACGCATTAACGGACA
ATGCTAAACGGTTCTATGAGCACATTGGTTTCGTCCCTTCACCACTTGACTCTATGATGTTGATGATAACGCTTGCCGAT
CTACAATTCGCATTGGGTATTCACCCGAACTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11048.58 Da        Isoelectric Point: 8.8707

>AT140692 WP_154450854.1 NZ_CP044328:462413-462709 [Methylocystis rosea]
MTRLSKSTQKEPTSPGRWVLQDAKARFSELVRRVRSEGPQHVTVHGRDAVVVVSAEEFRRLEGERTGDALIAAMQASPAR
EIDIEPKREAMPVREIEL

Download         Length: 297 bp

>AT140692 NZ_CP059347:c3823443-3823156 [Providencia rettgeri]
ATGTCGACTCAAAATGATGTTGCCGTGACTCGCTCATCTCTTAACCTGAGAATAAAACCGGAAGACAAAATCCTGATCGA
CCGTGCTGCGAATGCTGTGGGAAAAAACCGTACCGAATTTGTTCTGGAAGCAGCGCGGCGTGCAGCTGAAGAAACACTGG
CCGATCTGCGGGTGATTAACGTCAGCGCCGAGGTTTACCAAGAATTTATCAGCCAGCTTGATGCCGCGCCGAGTAGTAAT
GAGGCATTGAGGAAAACGATGATGTCTAAATCCCCTTGGGAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References