Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 35517..36146 Replicon chromosome
Accession NZ_CP044328
Organism Methylocystis rosea strain BRCS1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag F7D13_RS00200 Protein ID WP_154450566.1
Coordinates 35517..35912 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag F7D13_RS00205 Protein ID WP_154450567.1
Coordinates 35913..36146 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7D13_RS00180 31487..32419 - 933 WP_154450563.1 DUF3611 family protein -
F7D13_RS00185 32845..33189 + 345 WP_154450564.1 hypothetical protein -
F7D13_RS00190 33376..34017 + 642 WP_154450565.1 Kazal-type serine protease inhibitor domain protein -
F7D13_RS00195 34227..35417 + 1191 WP_018406022.1 elongation factor Tu -
F7D13_RS00200 35517..35912 - 396 WP_154450566.1 PIN domain-containing protein Toxin
F7D13_RS00205 35913..36146 - 234 WP_154450567.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
F7D13_RS00210 36319..36888 + 570 WP_154450568.1 NUDIX hydrolase -
F7D13_RS00215 36944..37252 - 309 WP_154450569.1 TonB-dependent receptor plug domain-containing protein -
F7D13_RS00220 37339..37551 - 213 WP_029648829.1 hypothetical protein -
F7D13_RS00225 37774..38550 + 777 WP_154450570.1 DUF1499 domain-containing protein -
F7D13_RS00230 38644..39648 + 1005 WP_154450571.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
F7D13_RS00235 39661..41133 + 1473 WP_154450572.1 pyruvate dehydrogenase complex E1 component subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(9-47)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14312.43 Da        Isoelectric Point: 6.7044

>T140691 WP_154450566.1 NZ_CP044328:c35912-35517 [Methylocystis rosea]
MRYMLDTNICSAVIKRRDAHVLDKFDAEAGRMCISSITLSELLFGAEKKRNAALDAALRDFAACIGVVPYDEAAAAHYGQ
LRAELERMGYPLGANDLFIAAHARSLGLALVTNDAAFDRAPGLRVENWLRG

Download         Length: 396 bp

>T140691 NZ_CP059347:2974769-2975077 [Providencia rettgeri]
ATGCAATATTGCCTCTATCAAAATCGAGAAGATACGGTTAAATACCCGTACTTACTGGATATTCAAAGTAATATTATTGA
TATATTGAATACTCGCTTAGTCATCCCGTTATTCGATAGTAGGCTTGTTAAAAAACCATTACCTGTACGCTTAAATCCAC
AATTATCAATCAACGGGCAGGTTTTTATTTTAATGACTCATCAAATGGCTTGTGTTCCTCTTTCATTACTAGGAAAAGAA
ATCGTTGATTTGACTCACCAACGAGACACGATTAAACACGCAGTTGACCTGCTTATTAATGGCTTTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8654.85 Da        Isoelectric Point: 7.0115

>AT140691 WP_154450567.1 NZ_CP044328:c36146-35913 [Methylocystis rosea]
MTTVATTIFQNNRTQAVRLPKAVAFPDTVKEVEIVVVGDSRIVSPAGKRFTEWAKRHPPFPDFERPSQPSLDDEAIF

Download         Length: 234 bp

>AT140691 NZ_CP059347:2974530-2974769 [Providencia rettgeri]
ATGAATACCACGGCTCAAAGAATGAAAAAAACCGTCAGTGTCACGGTGGCGCCTGAACTCTACGAACAAGCTAGGCAGGC
AAAACTTAACCTATCTGCAATACTAACGTGTGCCTTGCAGGCTGAATTAAAACGCCTAGAAGCGCAGAAATGGAAAAATG
AAAATAGAGAAGGTTTTAATGAGTTAAATAGGATCAATGAAGAACATGGATTACTCTCAGATAAATACAAGGATTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References