Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907(toxin) |
Location | 532912..533483 | Replicon | chromosome |
Accession | NZ_CP044316 | ||
Organism | Enterococcus faecium strain 15-307-1 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | Q3Y2B8 |
Locus tag | CWC51_RS02555 | Protein ID | WP_002286801.1 |
Coordinates | 533142..533483 (+) | Length | 114 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | A0A828ZZN9 |
Locus tag | CWC51_RS02550 | Protein ID | WP_002323011.1 |
Coordinates | 532912..533142 (+) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CWC51_RS02520 | 528048..529376 | + | 1329 | WP_008265691.1 | FAD-containing oxidoreductase | - |
CWC51_RS02525 | 529398..530024 | + | 627 | WP_002286816.1 | cysteine hydrolase | - |
CWC51_RS02530 | 530207..530788 | + | 582 | WP_002286813.1 | TetR/AcrR family transcriptional regulator | - |
CWC51_RS02535 | 531520..531867 | + | 348 | WP_002286808.1 | SOS response-associated peptidase family protein | - |
CWC51_RS02540 | 531843..532082 | + | 240 | WP_002321938.1 | SOS response-associated peptidase family protein | - |
CWC51_RS02545 | 532287..532625 | - | 339 | WP_002286804.1 | hypothetical protein | - |
CWC51_RS02550 | 532912..533142 | + | 231 | WP_002323011.1 | hypothetical protein | Antitoxin |
CWC51_RS02555 | 533142..533483 | + | 342 | WP_002286801.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
CWC51_RS02560 | 534333..534518 | + | 186 | WP_002304207.1 | hypothetical protein | - |
CWC51_RS02565 | 535023..535217 | + | 195 | WP_002297028.1 | hypothetical protein | - |
CWC51_RS02570 | 535375..535657 | + | 283 | Protein_510 | transposase | - |
CWC51_RS02575 | 535901..536731 | - | 831 | WP_002286789.1 | manganese catalase family protein | - |
CWC51_RS02580 | 536939..538273 | + | 1335 | WP_002286788.1 | ABC transporter substrate-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13302.68 Da Isoelectric Point: 9.9044
>T140684 WP_002286801.1 NZ_CP044316:533142-533483 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF
Download Length: 342 bp
>T140684 NZ_CP059346:c819402-819199 [Providencia alcalifaciens]
ATGACCAAATCCGATTATCTGATGCGTTTAAGAAAATGCACCACTATTGAAACACTTGAGCGCGTTATTGAAAAAAATAA
GTATGAGTTATCCGATGATGAGTTAGAGTTATTTTACTCTGCCGCTGATCATCGTCTTGCAGAGCTCACGATGAATAAAC
TTTACGATAAAATTCCAGCATCTGTTTGGAAGTTTGTTAGATAA
ATGACCAAATCCGATTATCTGATGCGTTTAAGAAAATGCACCACTATTGAAACACTTGAGCGCGTTATTGAAAAAAATAA
GTATGAGTTATCCGATGATGAGTTAGAGTTATTTTACTCTGCCGCTGATCATCGTCTTGCAGAGCTCACGATGAATAAAC
TTTACGATAAAATTCCAGCATCTGTTTGGAAGTTTGTTAGATAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8523.39 Da Isoelectric Point: 3.9078
>AT140684 WP_002323011.1 NZ_CP044316:532912-533142 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL
Download Length: 231 bp
>AT140684 NZ_CP059346:c819843-819475 [Providencia alcalifaciens]
ATGGATGAATACTCACCCAAGAAACATGATATAGCCGAATTAAAATATCTTTGTAACAGTTTGAATAGAGACGCTATATC
AAGTTTACAAAAAACAAACACTCATTGGATAAATGATCTTAGTTCTTCACAAAGCATCAGTCTTAACGAGCTTGTTGAGC
ATATTGCAGCTTTTGTCTGGCGATTTAAAATCAAATATCCAAAAGAAAATCTCGTTATTTCTCTTGTTGAAGAGTATCTT
GACGAAACATATAATTTATTTGGCAGCCCAGTAGTTACCTTCAGCGAAATCATTGACTGGGAAAGTATGAATCAAAATCT
TGTCGCCGTGCTCGATGATGATCTAAAATGTCTGACAAGTAAGACTTAG
ATGGATGAATACTCACCCAAGAAACATGATATAGCCGAATTAAAATATCTTTGTAACAGTTTGAATAGAGACGCTATATC
AAGTTTACAAAAAACAAACACTCATTGGATAAATGATCTTAGTTCTTCACAAAGCATCAGTCTTAACGAGCTTGTTGAGC
ATATTGCAGCTTTTGTCTGGCGATTTAAAATCAAATATCCAAAAGAAAATCTCGTTATTTCTCTTGTTGAAGAGTATCTT
GACGAAACATATAATTTATTTGGCAGCCCAGTAGTTACCTTCAGCGAAATCATTGACTGGGAAAGTATGAATCAAAATCT
TGTCGCCGTGCTCGATGATGATCTAAAATGTCTGACAAGTAAGACTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829FD66 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZZN9 |